Straightforward microwave-assisted synthesis of ultrasmall gold nanoparticles acnhored on reduced graphene oxide for enhanced antibacterial application

Fathurrohman, Pandji Zamzami and Kunarti, Eko Sri and Wijayanti, Nastiti and Santosa, Sri Juari (2024) Straightforward microwave-assisted synthesis of ultrasmall gold nanoparticles acnhored on reduced graphene oxide for enhanced antibacterial application. Discover Applied Sciences, 6 (6): 311. pp. 1-17. ISSN 30049261

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Abstract

Graphene derivative materials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have garnered significant attention from scientists for over two decades due to their distinctive characteristics and versatile applications across various fields, particularly in biomedical applications. Incorporating gold nanoparticles (AuNPs) into rGO sheets as rGO-Au nanocomposites further enhances its performance in biomedical applications. This study presents a rapid and efficient method for synthesizing ultrasmall AuNPs anchored on reduced graphene oxide (rGO-Au) using microwave irradiation and ascorbic acid. The optimum microwave treatment was 4 min, ensuring the highest GO reduction degree. Structural characterization by TEM reveals a distinctive architecture with ultrasmall AuNPs (average size of 2.2 nm) distributed on the rGO sheets. Interestingly, while the synthesized rGO-Au did not exhibit any antibacterial activities against both Escherichia coli and Staphylococcus aureus in disk diffusion assays, it demonstrated bacteriostatic effect at remarkably low concentrations when assessed by optical density measurement. The effective concentration of rGO-Au to inhibit E. coli growth was determined to be 2.5 ppm, while for S. aureus, it was 5 ppm, resulting in growth inhibition of 53.1 and 50.0, respectively. These findings provide a straightforward synthesis route for rGO-Au nanocomposites and underscore the importance of AuNPs’ size and quantity in modulating antibacterial properties. © The Author(s) 2024.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Hybrid Gold Open Access
Uncontrolled Keywords: Graphene oxide · Gold nanoparticles · Microwave synthesis · Antibacterial · Ascorbic acid
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Biology > Doctoral Program in Biology
Depositing User: Rusna Nur Aini Aini
Date Deposited: 13 Sep 2024 07:32
Last Modified: 13 Sep 2024 07:32
URI: https://ir.lib.ugm.ac.id/id/eprint/6655

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