In ovo inhibition of avian pox virus replication by mangosteen rind and red ginger ethanolic extracts

Nur’aini, Annisaa’ Lu’lu and Hartati, Sri and Untari, Tri (2021) In ovo inhibition of avian pox virus replication by mangosteen rind and red ginger ethanolic extracts. Veterinary World, 14 (10). pp. 2640-2645. ISSN 2231-0916

[thumbnail of In ovo inhibition of avian pox virus replication by mangosteen rind.pdf] Text
In ovo inhibition of avian pox virus replication by mangosteen rind.pdf - Published Version
Restricted to Registered users only

Download (770kB) | Request a copy

Abstract

Background and Aim: Avian pox is a contagious disease caused by the avian pox virus (APV). Mangostin and γ-mangostin
in mangosteen rind (MR) and gingerol in red ginger (RG) exhibit antiviral activity. In this study, we evaluated the effect of MR and RG ethanolic extracts on APV based on pock lesions on the chorioallantoic membrane (CAM) of specific pathogenfree (SPF) embryonated chicken eggs (ECEs).

Materials and Methods: Three APVs from chicken isolates (C1, C2, and C3), one APV from a pigeon isolate (P), 1.5%
and 3% MR ethanolic extract, 5% and 10% RG ethanolic extract, and a combination of 1.5% MR and 5% RG at 0.1 mL/
egg were inoculated in ovo (7th day incubation, chorioallantoic route) in SPF ECEs. A control group inoculated in ovo with APV alone was also established. Each treatment consisted of three replicates. Parameters including embryo survival, CAM lesions, and average number of pock lesions were determined.

Results: In ovo inoculation of MR and RG ethanolic extracts was not harmful to the ECEs and did not induce CAM lesions.
The average number of pock lesions in the control group (C1, C2, C3, and P) was 35, 14, 10, and 17, respectively, whereas
in all treatment groups, the number was 0, except in the 5% RG group of C1, which had a value of 10.

Conclusion: In ovo inoculation of 1.5% and 3% MR, 5% and 10% RG, and the combination of 1.5% MR plus 5% RG
ethanolic extract s at 0.1 mL/egg inhibit APV by reducing the number of pock lesions on the CAM of the ECE.

Item Type: Article
Uncontrolled Keywords: avian pox virus, in ovo, mangosteen rind, pock lesions, red ginger.
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 19 Sep 2024 05:40
Last Modified: 19 Sep 2024 05:40
URI: https://ir.lib.ugm.ac.id/id/eprint/7330

Actions (login required)

View Item
View Item