Oral subchronic toxicity of (+)-2,2’- epicytoskyrin a on male mice (Mus musculus)

Phadmacanty, Ni Luh Putu Rischa and Wulansari, Dewi and Agusta, Andria and Widyarini, Sitarina and Kurniasih, Kurniasih (2021) Oral subchronic toxicity of (+)-2,2’- epicytoskyrin a on male mice (Mus musculus). BIO Web of Conferences, 33: 06007. pp. 1-8. ISSN 22731709

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Abstract

(+)-2,2'- Epicytoskyrin A (EpiA) is a secondary metabolite
derived from an endophytic fungus Diaporthe sp. associated with the Gambier plant. EpiA has been reported to possess anticancer, antifungal, and antibacterial activities. In a mouse model, EpiA was also shown to low oral toxicity. Until now, there is no negative effect of EpiA reported yet.
This study aimed to study the subchronic toxicity of this component in mice. This study used 60 male mice (Mus musculus) which were divided into four groups of treatments. Parameters that were analyzed were body weight, food
consumption, blood chemicals, and histology. The results showed no significant difference in body weight gain and food consumption in all groups. Blood chemicals analysis showed increasing AST and ALT in dosage 12.5 mg/kg BW groups at day 90. Histological changes showed fatty degeneration and hydropic degeneration in the liver and mild inflammation
in the kidney. No irreversible toxic effect of this component. So it can be beneficial for plant-based drug discovery. On the other hand, this study provides information about the safety of the development of EpiA as a drug candidate.

Item Type: Article
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 23 Sep 2024 00:43
Last Modified: 23 Sep 2024 00:43
URI: https://ir.lib.ugm.ac.id/id/eprint/7390

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