The Effect of Colistin Administration as Medicated Feed on Alanine Aminotransferase and Creatinine Level in Broiler Infected with Escherichia coli

Fitri, Aisah Nurul and Fitriana, Ida and Rosetyadewi, Antasiswa Windraningtyas and Pratama, Anggi Muhtar and Septiana, Aria Ika and Setiawan, Dwi Cahyo Budi and Wijayanti, Agustina Dwi (2021) The Effect of Colistin Administration as Medicated Feed on Alanine Aminotransferase and Creatinine Level in Broiler Infected with Escherichia coli. BIO Web of Conferences, 33: 03002. pp. 1-8. ISSN 22731709

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Abstract

Colistin is a decapeptide antibiotic with narrow spectrum
activity, mainly used as treatment for Gram negative bacteria. This study aims to scientifically determine the effect of colistin administration as medicated feed on alanine aminotransferase (ALT) and creatinine level in
broiler infected with Escherichia coli. KTOP group as positive control, KTON group as negative control, while I, II, and III groups were infected with Escherichia coli 1 x 108 CFU/ml 0.1 ml via intratracheal route. Group
I, II, and III were given colistin treatment dosage of 0.3 g/kg food, 0.6 g/kg food, and 1.2 g/kg food. Blood samples were taken through brachial veins for ALT and creatinine examination with a Caretium NB-201 semi-auto
chemistry analyzer. Data were examined statistically using IBM SPSS Statistics 24 software and graphically using Microsoft Excel 365. Conclusion of the research by statistical analysis with Kruskal-Wallis test
obtained ALT test results P = 0.147 and creatinine test results P = 0.815. Based on the results of this study, the administration of colistin medicated feed did not cause a significant effect on ALT and creatinine level in broiler
infected with Escherichia coli, indicating that colistin has low potential toxicity while given as medicated feed.

Item Type: Article
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 23 Sep 2024 00:39
Last Modified: 23 Sep 2024 00:39
URI: https://ir.lib.ugm.ac.id/id/eprint/7394

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