Challenges in the Vaccination of the Elderly and Strategies for Improvement

Soegiarto, Gatot and Purnomosari, Dewajani (2023) Challenges in the Vaccination of the Elderly and Strategies for Improvement. Pathophysiology, 30 (2). pp. 155-173. ISSN 09284680

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Abstract

In recent years, the elderly has become a rapidly growing proportion of the world’s
population as life expectancy is extending. Immunosenescence and inflammaging contribute to the
increased risk of chronic non-communicable and acute infectious diseases. Frailty is highly prevalent
in the elderly and is associated with an impaired immune response, a higher propensity to infection,
and a lower response to vaccines. Additionally, the presence of uncontrolled comorbid diseases in
the elderly also contributes to sarcopenia and frailty. Vaccine-preventable diseases that threaten the
elderly include influenza, pneumococcal infection, herpes zoster, and COVID-19, which contribute
to significant disability-adjusted life years lost. Previous studies had shown that conventional
vaccines only yielded suboptimal protection that wanes rapidly in a shorter time. This article reviews
published papers on several vaccination strategies that were developed for the elderly to solve these
problems: more immunogenic vaccine formulations using larger doses of antigen, stronger vaccine
adjuvants, recombinant subunit or protein conjugated vaccines, newly developed mRNA vaccines,
giving booster shots, and exploring alternative routes of administration. Included also are several
publications on senolytic medications under investigation to boost the immune system and vaccine
response in the elderly. With all those in regard, the currently recommended vaccines for the elderly
are presented.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: elderly; frailty; immunosenescence; infection; recommended vaccine; comparative effectiveness analysis
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Ani PURWANDARI
Date Deposited: 15 Jul 2024 04:42
Last Modified: 15 Jul 2024 04:42
URI: https://ir.lib.ugm.ac.id/id/eprint/750

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