The effect of zinc oxide (ZnO) nanoparticle concentration on the adhesion of mucin and Streptococcus mutans to heat-cured acrylic resin

Incorporating zinc oxide (ZnO) nanoparticles as antibacterial fillers in heat-cured acrylic resin could decrease mucin and Streptococcus mutans (S. mutans) adhesion, reducing the incidence of dental caries in the baseplates of orthodontic patients. Here, ZnO nanoparticles were modified using 3-(trimethoxysilyl)propyl methacrylate with various concentrations, added to acrylic resin powder, homogenized, mixed with acrylic resin liquid, and processed. The composite systems interfered well with mucin and S. mutans adhesion. The lowest mean of the amount of mucin adhered was on heat-cured acrylic resin with 7.5 ZnO nanoparticles, with a standard deviation of 18.07±0.80 mg/mL. The ZnO nanoparticles with a concentration of 7.5 showed an 87.09±0.88 S. mutans adhesion in control groups with no additives. These composite systems were proven to have better physicochemical characteristics and antibacterial abilities. Combining ZnO nanoparticles with heat-cured acrylic resin has great potential for self-cleaning baseplates of orthodontic patients in the future. © 2023, Japanese Society for Dental Materials and Devices. All rights reserved.