Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies

Fujihara, Chiharu and Hafiyyah, Osa Amila and Murakami, Shinya (2023) Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies. Japanese Dental Science Review, 59. 357 – 364. ISSN 18827616

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Abstract

Aggressive periodontitis (AgP), Stage III or IV and Grade C according to the new periodontitis classification, is characterized by the rapid destruction of periodontal tissues in the systemically healthy population and often causes premature tooth loss. The presence of familial aggregation suggests the involvement of genetic factors in the pathogenesis. However, the genes associated with the onset and progression of the disease and details of its pathogenesis have not yet been fully identified. In recent years, the genome-wide approach (GWAS), a comprehensive genome analysis method using bioinformatics, has been used to search for disease-related genes, and the results have been applied in genomic medicine for various diseases, such as cancer. In this review, we discuss GWAS in the context of AgP. First, we introduce the relationship between single-nucleotide polymorphisms (SNPs) and susceptibility to diseases and how GWAS is useful for searching disease-related SNPs. Furthermore, we summarize the recent find

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Aggressive periodontitis (AgP); Genome-wide association studies (GWAS; Single-nucleotide polymorphisms (SNPs)
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dental Study Program Academic Phase
Depositing User: Desy Natalia Anggorowati Anggorowati
Date Deposited: 10 Oct 2024 06:35
Last Modified: 10 Oct 2024 06:35
URI: https://ir.lib.ugm.ac.id/id/eprint/8356

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