Fabrication and Physicochemical Properties of a Novel Gel-Like Liquid Chitosan-Carbonated Hydroxyapatite from Asian Moon Scallop (Amusium Pleuronectes) for Periodontal Application

Asian moon scallop (Amusium pleuronectes) is known as indigenous species and serves as an alternative good source of calcium for bone grafts. Bone graft for periodontal application need to consider the effects of microbial load in the periodontal site defect. Chitosan is added to increase its antimicrobial properties. Gel-like liquid chitosan/carbonated hydroxyapatite (CS/CHA) synthesized as a material for regenerating narrow and irregular periodontal defects. The aim of this study was to synthesize and evaluate the physicochemical properties of gel-like liquid CS/CHA from Asian moon scallop for periodontal regeneration. CHA was synthesized using a co-precipitation method. CS/CHA gel-like liquids were fabricated using a mixing method with various CHA concentrations. The CS/CHA gel-like liquids’ physicochemical properties were evaluated using Fourier-transform infrared spectroscopy (FTIR), without X-ray diffraction (XRD), pH meter, viscometer, Atomic Absorption Spectrophotometry and Scanning Electron Microscopy– Energy Dispersive X-ray spectroscopy (SEM–EDX). The results of CHA characterization showed that CHA successfully synthesized with optimal physicochemical properties. The characterization of gel-like liquid CS/CHA confirmed that FTIR spectra showed intermolecular bonds, the highest XRD peak in the gel-like liquid is the CS/CHA 5 gel, CHA crystal spreads in the chitosan gel-like liquid, has a good injectability and the pH is neutral. In conclusion, CS/CHA 5 meets the requirements as an injectable material that can be applied for periodontal regeneration. © 2023, Journal of International Dental and Medical Research. All Rights Reserved.