Asih, Tri Sri Noor and Widodo, Widodo and Dewi, Dwi Rizkiana (2021) Optimal Control on a Model for Cervical Cancer. In: Lecture Notes in Computational Science and Engineering ((LNCSE,volume 139)).
Full text not available from this repository. (Request a copy)Abstract
Cervical cancer is caused by the human Papillomavirus (HPV) that attacks the cervix. Cervical cancer globally ranks third as the most frequent cancer among women. In this research, a model of HPV infection in cervical cancer consists of five sub categories of cells, namely susceptible cells, infected cells, pre-cancer cells, cancer cells, and viruses. The study was conducted by forming a model of HPV infection with the addition of treatment controls on pre-cancerous cells. The aim is to minimize the number of pre-cancerous cells while minimizing cost. The HPV infection model with control was solved using Pontryagin’s maximum principle in order to obtain optimal control. Numerical simulations are performed on the differential equations for the cell densities using the fourth order Runge-Kutta method. The simulation results indicate that a smart administration of treatment can be tailored such that the number of pre-cancer cells is minimized at minimal cost. This configuration with a minimal number of pre-cancer cells is favourable since it inhibits the development of cancer cells. © 2021, Springer Nature Switzerland AG.
Item Type: | Conference or Workshop Item (Paper) |
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Additional Information: | Cited by: 0 |
Uncontrolled Keywords: | Cytology; Differential equations; Diseases; Numerical methods; Oncogenic viruses; Runge Kutta methods; Cancerous cells; Cervical cancers; Fourth order Runge-Kutta methods; Human papillomavirus; Infected cells; Infection models; Minimizing costs; Optimal controls; Cells |
Subjects: | Q Science > QA Mathematics |
Divisions: | Faculty of Mathematics and Natural Sciences > Computer Science & Electronics Department |
Depositing User: | Sri JUNANDI |
Date Deposited: | 06 Oct 2024 23:17 |
Last Modified: | 06 Oct 2024 23:17 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/8720 |