Biopolymer-based polycaprolactone-hydroxyapatite scaffolds for bone tissue engineering

Aminatun, Aminatun and Suciati, Tri and Sari, Yessie Widya and Sari, Mona and Alamsyah, Kartika A. and Purnamasari, Wulan and Yusuf, Yusril (2023) Biopolymer-based polycaprolactone-hydroxyapatite scaffolds for bone tissue engineering. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 72 (5). pp. 376-385. ISSN 0091-4037

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Abstract

This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46-91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 +/- 1.36) MPa, (0.81 +/- 0.09) MPa, and (61.5 +/- 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.

Item Type: Article
Uncontrolled Keywords: Bone tissue engineering; common cockle shells; composite nanofiber scaffold; hydroxyapatite
Subjects: Q Science > QC Physics
Divisions: Faculty of Mathematics and Natural Sciences > Physics Department
Depositing User: Sri JUNANDI
Date Deposited: 14 Oct 2024 07:04
Last Modified: 14 Oct 2024 07:04
URI: https://ir.lib.ugm.ac.id/id/eprint/9356

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