Aminatun, Aminatun and Suciati, Tri and Sari, Yessie Widya and Sari, Mona and Alamsyah, Kartika A. and Purnamasari, Wulan and Yusuf, Yusril (2023) Biopolymer-based polycaprolactone-hydroxyapatite scaffolds for bone tissue engineering. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 72 (5). pp. 376-385. ISSN 0091-4037
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This work synthesized Hydroxyapatite (HA) from common cockle shells using a precipitation method and fabricated nanofiber scaffolds of polycaprolactone (PCL)-HA composites with combinations of several polymers (i.e., gelatin, chitosan, and collagen) using electrospinning. The synthesized HA had a small agglomerate shape, solid structure, and few interconnected micropores. Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the synthesized HA exhibited a Ca/P molar ratio of 1.68. All nanofiber samples were nontoxic with cell viability values of 70.46-91.78%. The PCL-HA-Gelatin nanofiber was the best mechanical properties of the scaffold with the high values of tensile strength, modulus of elasticity, and breaking-point elongation at (9.80 +/- 1.36) MPa, (0.81 +/- 0.09) MPa, and (61.5 +/- 7.75) %, respectively. There was no significant difference in the average cell viability of the samples. Nanofiber scaffolds of PCL-HA polymer have the potential for bone tissue engineering applications by satisfying their mechanical property and cytotoxicity assay criteria.
Item Type: | Article |
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Uncontrolled Keywords: | Bone tissue engineering; common cockle shells; composite nanofiber scaffold; hydroxyapatite |
Subjects: | Q Science > QC Physics |
Divisions: | Faculty of Mathematics and Natural Sciences > Physics Department |
Depositing User: | Sri JUNANDI |
Date Deposited: | 14 Oct 2024 07:04 |
Last Modified: | 14 Oct 2024 07:04 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/9356 |