Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors

von Schirnding, Constantin and Giopanou, Ioanna and Hermawan, Adam and Wehl, Lisa and Ntaliarda, Giannoula and Illes, Bernhard and Datz, Stefan and Geisslinger, Franz and Bartel, Karin and Sommer, Ann-Katrin and Lianou, Marina and Weiss, Veronika and Feckl, Johann and Vollmar, Angelika M. and Brauchle, Christoph and Stathopoulos, Georgios T. and Wagner, Ernst and Roidl, Andreas and Bein, Thomas and Engelke, Hanna (2021) Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors. CHEM, 7 (2). pp. 480-494. ISSN 2451-9294

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Abstract

Conventional chemotherapy leads to severe adverse effects since it involves systemic administration of toxic drugs at high dosage. Unlike traditional chemotherapeutics, calcium phosphate and citrate have both been discussed as very promising anticancer agents and are not inherently toxic. Yet, their breakthrough has been hampered by the lack of an administration approach that overcomes the strict regulatory mechanisms of the cell. Here, we present a combinatorial administration of calcium, phosphate, and citrate as colloidal, amorphous nanoparticles (CPCs) that selectively kill cancer cells without involvement of inherently toxic drugs. The particles are toxic neither before endosomal release nor after their degradation. This highly selective toxicity allowed us to successfully treat two different aggressive pleural tumors in mice, reducing their size by about 40% and 70% after only two local applications. Safety assessment studies over 2 months show no signs of adverse effects except for slightly enhanced pleural thickening after eight applications.

Item Type: Article
Subjects: R Medicine > RP Public Health and Nutrition
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 14 Oct 2024 02:47
Last Modified: 14 Oct 2024 02:47
URI: https://ir.lib.ugm.ac.id/id/eprint/9391

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