Dewanti, Ajeng Istyorini Asmoning and Kunjirika, Tony Prince and Putri, Raden Roro Risang Ayu Dewayani and Adaninggar, Ascarti and Raharjeng, Anita Restu Puji and Retnoaji, Bambang and Nuriliani, Ardaning and Sofyantoro, Fajar and Septriani, Nur Indah and Saragih, Hendry T. S. S. G. (2023) Effects of Paracetamol on the Development of Zebrafish (Danio rerio). Pertanika Journal of Tropical Agricultural Science, 46 (4). 1173 -1188. ISSN 15113701
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Abstract
The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.
Item Type: | Article |
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Additional Information: | Library Dosen |
Uncontrolled Keywords: | Danio rerio; embryo development; paracetamol; pigmentation; zebrafish |
Subjects: | Biology |
Divisions: | Faculty of Biology > Doctoral Program in Biology |
Depositing User: | Rusna Nur Aini Aini |
Date Deposited: | 18 Dec 2024 01:22 |
Last Modified: | 18 Dec 2024 01:22 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/9608 |