Primate Simplexviruses Differ in Tropism for Macaque Cells

Hofmann-Winkler, Heike and Siregar, Abdul Rahman and Esiyok, Nesil and Rodríguez-Polo, Ignacio and Gärtner, Sabine and Behr, Rüdiger and Pöhlmann, Stefan and Winkler, Michael (2022) Primate Simplexviruses Differ in Tropism for Macaque Cells. Microorganisms, 11 (1). pp. 1-14. ISSN 20762607

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Abstract

Primate simplexviruses are closely related neurotropic herpesviruses, which are largely apathogenic in their respective host species. However, cross-species transmission of Macacine alphaherpesvirus 1 (McHV1, also termed herpes B virus) from rhesus macaques to humans can cause fatal encephalomyelitis. In contrast, closely related viruses, such as Cercopithecine alphaherpesvirus 2 (CeHV2, also termed simian agent 8) or Papiine alphaherpesvirus 2 (PaHV2, also termed herpesvirus papio 2), have not been linked to human disease and are believed to be largely apathogenic in humans. Here, we investigated whether McHV1, PaHV2 and CeHV2 differ in their capacity to infect human and non-human primate (NHP) cells. For comparison, we included the human simplexviruses HSV1 and HSV2 in our analyses. All five viruses replicated efficiently in cell lines of human and African green monkey origin, and McHV1 and PaHV2 also showed robust replication in rhesus macaque cell lines. In contrast, the replication of CeHV2 and particula

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: Macacine alphaherpesvirus 1; Cercopithecine alphaherpesvirus 2; Papiine alphaherpesvirus 2; tropism; rhesus macaque; non-human primate; iPS cell; neural aggregat
Subjects: Biology
Divisions: Faculty of Biology > Doctoral Program in Biology
Depositing User: Rusna Nur Aini Aini
Date Deposited: 16 Oct 2024 08:01
Last Modified: 16 Oct 2024 08:01
URI: https://ir.lib.ugm.ac.id/id/eprint/9665

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