The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent

Kayati, Fitri Nur and Purnomo, Chandra Wahyu and Kusumastuti, Yuni and Rochmadi, Rochmadi (2023) The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent. Green Processing and Synthesis, 12 (1).

[thumbnail of The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent.pdf] Text
The optimization of hydrogel strength from cassava starch using oxidized sucrose as a crosslinking agent.pdf
Restricted to Registered users only

Download (4MB) | Request a copy

Abstract

The mechanical properties of hydrogels are crucial in wound dressing application. Starch-based hydrogels have deficiencies in mechanical strength and gel stability. These shortcomings can be addressed by employing crosslinking techniques with oxidized sucrose. A design of experiments approach was used to optimize the tensile strength of the product. The results indicated that both the composition of oxidized sucrose and glycerol significantly impact tensile strength (p-value \textless 0.05). The optimal tensile strength achieved was 27 MPa, using 0.9762 mL of oxidized sucrose and 0.0624 g of glycerol per gram of starch. The hydrogel products underwent a series of characterizations, including optical microscope examination, Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance (1H NMR), swelling test, Water Vapor Transmission Rate (WVTR), contact angle, and cytotoxicity test. The FTIR and 1H NMR analyses confirmed the crosslinking of hydroxyl groups within starch molecules with aldehyde groups from oxidized sucrose. Characterization of this hydrogel revealed that it had a swelling capacity of 95%, a WVTR of 714.92 g per m2 per 24 h, a contact angle of 74.76°, and a cell viability value greater than 100%. Thus, this hydrogel is suitable for wound dressing due to its strength, exudate-absorbing capabilities, moisture retention properties, hydrophilicity, and non-toxicity.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: hydrogel film, starch, oxidized sucrose, central composite design, wound dressing
Subjects: T Technology > TP Chemical technology
Divisions: Faculty of Engineering > Chemistry Engineering Department
Depositing User: Rita Yulianti Yulianti
Date Deposited: 19 Aug 2024 02:04
Last Modified: 19 Aug 2024 02:04
URI: https://ir.lib.ugm.ac.id/id/eprint/106

Actions (login required)

View Item
View Item