Sofian, Ferry Ferdiansyah and Warahapsari, Fatimah Ayu and Yoshida, Jun and Ito, Yoshiaki and Koseki, Takuya and Shiono, Yoshihito (2023) Two new octahydronaphthalene derivatives, trichodermic acids C and D produced by Trichoderma sp. HN-1.1. Natural Product Research, 37 (3). 484 – 493. ISSN 14786419
Full text not available from this repository. (Request a copy)Abstract
Two new octahydronaphthalene derivatives, trichodermic acid C (1) and trichodermic acid D (2), along with known analogs, trichodermic acid (3), trichodermic acid A (4) and trichodermic acid B (5), were isolated from an ethyl acetate extract of endophytic strain Trichoderma sp. HN-1.1. The structures of compounds 1 and 2 were elucidated using spectroscopic methods including UV, IR, HRESITOFMS, ECD, 1 D and 2 D NMR. The cytotoxic activity of the isolated compounds was evaluated on the rat hepatoma cell line H4IIE, using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. According to the results, only compound 3 showed a significant reduction of H4IIE cells from 75 to 21 (p < 0.01) with an IC50 value of 50 cell survival estimated as 143.1 µM, which indicated weak cytotoxic activity. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Item Type: | Article |
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Additional Information: | Cited by: 4 |
Uncontrolled Keywords: | Animals; Antineoplastic Agents; Cell Line; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Trichoderma; antineoplastic agent; animal cell; animal experiment; article; cell survival; controlled study; cytotoxicity; electronic circular dichroism; endophyte; H4-II-E cell line; IC50; male; MTT assay; nonhuman; nuclear magnetic resonance; rat; Trichoderma; animal; cell line; chemical structure; chemistry; nuclear magnetic resonance spectroscopy |
Subjects: | S Agriculture > SD Forestry |
Divisions: | Faculty of Forestry > Departemen Tehnologi Hasil Hutan |
Depositing User: | Sri JUNANDI |
Date Deposited: | 05 Nov 2024 06:57 |
Last Modified: | 05 Nov 2024 06:57 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/10884 |