Thermosensitive hydrogels as drug carriers for breast cancer treatment: a systematic review

Thermo-sensitive hydrogel is a drug delivery system in breast cancer therapy,
where the influence of environmental temperature changes will affect the
characteristics of the polymer base. This study aimed to determine the
effectiveness of polymers in thermo-sensitive hydrogel bases as drug carriers
in breast cancer therapy and compared them with traditional intravenous drug
release. This study used a systematic literature review (SLR) using selected
reporting items for systematic review and meta-analysis guidelines
(PRISMA) (P), based on predetermined inclusion criteria, namely English
article, thermos-sensitive hydrogel, breast cancer, and original article. An
initial database search yielded 618 articles, PubMed (241), Scopus (364), and
the Directory of Open Access Journals (DOAJ) (36). To maintain the quality
of the data studied in this article, researchers used inclusion and exclusion
criteria, where the exclusion criteria used were non-English languages, review
articles, proceedings, communications, video articles, and not open access.
After the article screening process, 11 articles were obtained which would
then be summarized in data extraction. The conclusion of this study shows
that the thermos-sensitive hydrogel drug delivery system has advantages in
drug release, where the drug will be released continuously, but also has the
disadvantage of uncontrolled drug release.