Rusminingsih, Esri and Susanto, Hardhono and Afifah, Diana N. and Martien, Ronny and Subagyo, Hertanto Wahyu (2023) Effectiveness of Moringa oleifera Nanoparticles (Self Nano Emulsifying Drug Delivery System) on Insulin Resistance in the Prediabetes Rattus norvegicus Model. Tropical Journal of Natural Product Research, 7 (11). pp. 5059-5066. ISSN 26160684
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Abstract
The present study aimed to investigate the effect of Moringa oleifera nanoparticles (MoNP) supplementation based on the Self Nano Emulsifying Drug Delivery System on insulin resistance in prediabetes models. Twenty-five Rattus norvegicus were split into five groups, containing five rats each: normal control group (given a standard diet), as well as a prediabetes control group and three intervention groups fed a high-fat diet for four weeks. Those with fasting blood serum (FBS) ranged betwen 100-130 mg/dL were deemed prediabetic. The intervention groups were then given MoNP at dosages of 75, 125, and 225 mg/kg bw, respectively, whereas the normal and prediabetic groups received a regular diet. FBS, fasting insulin, TNF-α, IL-6, triglycerides, and HOMA-IR were all examined after treatment. MoNP significantly reduced TNF-α, IL-6, triglycerides, and HOMA-IR levels (p<0.05). It also generated a considerable rise in insulin levels in contrast to the prediabetic control group (p<0.05). Supplementation of MoNP at the lowest dose of 75 mg/kg body weight was able to lower FBS to normal levels from 130.04 mg/dL to 97.34 mg/dL and reduce HOMA-IR from 4.20 to 3.71 (p < 0.05). The administration of MoNP can reduce inflammatory cytokines and insulin resistance in the prediabetes model. © 2023 Rusminingsih et al.
Item Type: | Article |
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Additional Information: | Cited by: 1; All Open Access, Hybrid Gold Open Access |
Uncontrolled Keywords: | cytokine; glucose; interleukin 6; nanoparticle; plant extract; triacylglycerol; tumor necrosis factor; animal experiment; animal model; Article; blood sampling; body weight; controlled study; dispersity; drug delivery system; drug efficacy; extraction and extracts; fasting blood glucose level; fasting insulin level; homeostasis model assessment; impaired glucose tolerance; insulin resistance; lipid diet; male; Moringa oleifera; nonhuman; randomized controlled trial; rat; Rattus norvegicus; triacylglycerol blood level; ultraviolet spectrophotometry; zeta potential |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Depositing User: | Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah |
Date Deposited: | 16 May 2024 01:52 |
Last Modified: | 16 May 2024 01:52 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/1183 |