In vitro and In vivo Study of Gastroprotective effect of Purified Extract Andrographis paniculata

Pusmarani, Jastria and Dewi, Citra and Putri, Risky Juliansyah and Halid, Nur Hatidjah Awaliyah and Febriani, Sasri Intan and Husni, Febrianti and Purwono, Setyo and Ikawati, Zullies (2023) In vitro and In vivo Study of Gastroprotective effect of Purified Extract Andrographis paniculata. Research Journal of Pharmacy and Technology, 16 (8). 3615 – 3621. ISSN 09743618

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Abstract

Gastric ulcers are caused by excessive gastric acid secretion, alcohol, and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin is one of the NSAIDS that can induce peptic ulcers. Traditional medicines that have been proven to have gastroprotective activity is Andrographis paniculata (APAC). The purpose of this study is to assess the antioxidant activity and gastroprotective effect of purified extract of APAC. The herbal treatment was given for 7 days, and on the eighth day, all groups except the negative control (Na CMC 0.5) were given 1000mg/kgBW of aspirin. Six hours later, the rats were sacrificed and opened for macroscopic examination, pH gastric juice value, the volume of gastric value, ulcer index, and inhibition percentage. Antioxidant studies using 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that APAC has strong antioxidant activity with IC50 value = 64.54. APAC could reduce the occurrence of gastric ulcers by decreasing gastric pH, ulcer index, and increasing inhibition percentage (P=0.000<0.05). Andrographis paniculata has gastroprotective properties associated with antioxidant activity. © RJPT All Rights reserved..

Item Type: Article
Additional Information: Cited by: 0
Uncontrolled Keywords: acetylsalicylic acid; alkaloid; flavonoid; nonsteroid antiinflammatory agent; plant extract; saponin; steroid; terpenoid; Andrographis paniculata; angiogenesis; animal experiment; animal model; animal tissue; antioxidant activity; Article; cell infiltration; controlled study; DPPH radical scavenging assay; IC50; male; nonhuman; rat; stomach acid; stomach disease; stomach juice; stomach mucosa; stomach pH; stomach ulcer; ulcer index
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah
Date Deposited: 16 May 2024 01:06
Last Modified: 16 May 2024 01:06
URI: https://ir.lib.ugm.ac.id/id/eprint/1214

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