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Abstract
Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95 uncertainty interval UI 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% 12·41–17·87 in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Item Type: | Article |
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Additional Information: | Cited by: 10; All Open Access, Green Open Access |
Uncontrolled Keywords: | Adult; Aged; Databases, Factual; Female; Global Burden of Disease; Humans; Income; Male; Middle Aged; Peripheral Arterial Disease; Risk Factors; glucose; sodium; adult; aged; Article; disability-adjusted life year; epidemiological data; female; global prevalence; global disease burden; glucose blood level; high income country; human; hypertension; incidence; kidney failure; low income country; male; middle aged; middle income country; morbidity; mortality rate; peripheral arterial disease; prevalence; risk factor; smoking; sociodemographic index; sociodemographics; very elderly; years lived with disability; years of life lost; factual database; income; risk factor |
Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
Divisions: | Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition |
Depositing User: | Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah |
Date Deposited: | 16 May 2024 07:31 |
Last Modified: | 16 May 2024 07:31 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/1231 |