Electrochemical paper-based devices: Sensing approaches and progress toward practical applications

Noviana, Eka and McCord, Cynthia P. and Clark, Kaylee M. and Jang, Ilhoon and Henry, Charles S. (2020) Electrochemical paper-based devices: Sensing approaches and progress toward practical applications. Lab on a Chip, 20 (1). 9 – 34. ISSN 14730197

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Abstract

Paper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. When combined with electrochemical detection using small and portable electronics, sensitivity and selectivity of the paper devices can be improved over naked eye detection without sacrificing portability. Herein, we review how the field of electrochemical paper-based analytical devices (ePADs) has grown since it was introduced a decade ago. We start by reviewing fabrication methods relevant to ePADs with more focus given to the electrode fabrication, which is fundamental for electrochemical sensing. Multiple sensing approaches applicable to ePADs are then discussed and evaluated to present applicability, advantages and challenges associated with each approach. Recent applications of ePADs in the fields of clinical diagnostics, environmental testing, and food analysis are also presented. Finally, we discuss how the current ePAD technologies have progressed to meet the analytical and practical specifications required for field and/or POC applications, as well as challenges and outlook. This journal is © The Royal Society of Chemistry.

Item Type: Article
Additional Information: Cited by: 257
Uncontrolled Keywords: Electrochemical Techniques; Humans; Lab-On-A-Chip Devices; Paper; Point-of-Care Testing; Ability testing; Analytic equipment; Environmental testing; Eye protection; Clinical diagnostics; ELectrochemical detection; Electrochemical sensing; Electrode fabrication; Naked-eye detection; Paper based devices; Paper-based analytical devices; Portable electronics; Article; electrochemiluminescence; enzymatic assay; human; limit of detection; nonhuman; point of care testing; potentiometry; priority journal; sensitivity analysis; electrochemical analysis; lab on a chip; paper; point of care testing; Chemical detection
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 28 May 2025 06:46
Last Modified: 28 May 2025 06:46
URI: https://ir.lib.ugm.ac.id/id/eprint/16897

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