Complete Remission of Relapsed Hodgkin's Lymphoma following Brentuximab Vedotin and Gemcitabine Combination Therapy with Severe Hypotension as Possible Treatment-Related Adverse Event: A Case Report

Purwanto, Ibnu and Utomo, Bambang P. and Ghozali, Ahmad (2020) Complete Remission of Relapsed Hodgkin's Lymphoma following Brentuximab Vedotin and Gemcitabine Combination Therapy with Severe Hypotension as Possible Treatment-Related Adverse Event: A Case Report. CASE REPORTS IN ONCOLOGY, 13 (1). pp. 341-346. ISSN 1662-6575

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Abstract

A 40-year-old Asian female with heavily treated relapsed Hodgkin’s lymphoma showed complete
remission (CR) after receiving 8 cycles of brentuximab vedotin (BV) in combination with
gemcitabine as 4th line treatment. The patient remained in CR at the 18-month post-treatment
follow-up. She developed severe hypotension (50/36 mm Hg) with upper and lower limb
petechiae and edema after the addition of gemcitabine on the 6th cycle of BV. This adverse
event resolved after 3 days of treatment with vasopressor and high-dose corticosteroid. The
addition of dexamethasone for the subsequent 2 cycles successfully prevented this adverse
event from recurring.

Item Type:	Article
Additional Information:	Library Dosen
Uncontrolled Keywords:	Hodgkin’s lymphoma; Relapsed; Brentuximab; Complete remission; Adverse event
Subjects:	R Medicine > RP Public Health and Nutrition R Medicine > RT Nursing
Divisions:	Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User:	Sri JUNANDI
Date Deposited:	22 May 2025 01:37
Last Modified:	22 May 2025 01:37
URI:	https://ir.lib.ugm.ac.id/id/eprint/17450

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