Handani, Dewa A S and Hermawan, Adam and Ikawati, Zullies (2024) Correlation of ACE insertion/deletion gene polymorphism with captopril effectiveness in Indonesian hypertensive patients. Pharmacogenomics, 25 (8-9). 357 – 365. ISSN 14622416
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Background: Hypertension is a prevalent health concern in Indonesia, with a high percentage of patients unresponsive to ACE inhibitor treatment. Methods: This multicenter case-control study investigated the correlation between ACE I/D and captopril effectiveness in Indonesian hypertensive patients. Hypertensive patients were divided into control (n = 69) and case (n = 73) groups. ACE I/D was identified using PCR and electrophoresis. Results: No significant differences in genotype frequencies or allele distribution were observed. The difference of blood pressure reduction among the three genotypes also lacked statistical significance. Conclusion: ACE I/D is not significantly associated with blood pressure reduction following captopril therapy in Indonesian hypertensive patients. These results underscore the limited predictive utility of ACE I/D in managing hypertension with captopril. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Additional Information: | Cited by: 0 |
| Uncontrolled Keywords: | Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Case-Control Studies; Female; Gene Frequency; Genotype; Humans; Hypertension; INDEL Mutation; Indonesia; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; captopril; ACE protein, human; antihypertensive agent; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; ACE gene; adult; Article; blood pressure regulation; case control study; clinical effectiveness; clinical feature; controlled study; drug effect; drug efficacy; drug response; female; gene; gene deletion; gene frequency; gene insertion; genetic association; genetic polymorphism; genotype; human; hypertension; Indonesian; major clinical study; male; multicenter study; observational study; polymerase chain reaction; risk factor; treatment outcome; aged; blood pressure; clinical trial; drug therapy; genetic polymorphism; genetics; hypertension; indel mutation; Indonesia; middle aged |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Muh Aly Mubarok |
| Date Deposited: | 03 Jul 2025 00:30 |
| Last Modified: | 03 Jul 2025 00:30 |
| URI: | https://ir.lib.ugm.ac.id/id/eprint/19208 |
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