The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients

Virginia, Dita Maria and Patramurti, Christine and Hendra, Phebe and Lorenza, Paulina Nadya Feranti Pebby and Ngai, Faustina Evania and Anastasia, Novita and Defi, Matea Nirmala and Wahyuningsih, Mae Sri Hartati and Nugrahaningsih, Dwi Aris Agung (2023) The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients. Journal of Pharmacy and Pharmacognosy Research, 11 (2). pp. 255-262. ISSN 07194250

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Abstract

Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a high frequency of mutants in the rs2075604 as the intron area in the STK11 gene. Aims: To analyze the effect of rs2075604 related to lipid abnormalities in newly diagnosed T2DM patients. Methods: This present study conducted a cross-sectional study in the ten public healthcare facilities in Sleman, Yogyakarta. The genetic variants were detected using PCR-RFLP methods. A total of 130 patients who had to consume antidiabetic oral for three months participated in this study. Results: This study revealed that the mutant variant dominated in this population at 61.5. Mutant genotype, mutant allele, and dominant model reduce the risk of low HDL (OR = 0.33, 95 CI = 0.11-0.99; OR = 0.46, 95 CI = 0.24-0.90; OR = 0.33, 95 CI = 0.12-0.96; respectively). The improvement of low HDL risk by the mutant allele was confirmed through an adjusted model (OR = 0.47, 95 CI = 0.23-0.98). The mutant allele only influenced high LDL risk in the non-adjusted model (OR = 2.22, 95 CI = 1.02-4.82), but it did not found in other models. Conclusions: The mutant of rs2075604 has a protective role in low HDL-c risk in Indonesia. However, further study is required to observe the effect on LDL-c. © 2023 Journal of Pharmacy & Pharmacognosy Research.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: acarbose; glimepiride; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; metformin; protein kinase LKB1; rs2075604; sulfonylurea; unclassified drug; adult; allele; Article; cross-sectional study; electrophoresis; fasting blood glucose level; female; genetic model; genetic variability; genotype; glucose blood level; high density lipoprotein cholesterol level; human; lipid fingerprinting; low density lipoprotein cholesterol level; major clinical study; male; middle aged; mutant; non insulin dependent diabetes mellitus; polymerase chain reaction restriction fragment length polymorphism; risk factor; single nucleotide polymorphism
Subjects: R Medicine > RC Internal medicine
R Medicine > RT Nursing
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 03 Jun 2024 03:25
Last Modified: 03 Jun 2024 03:25
URI: https://ir.lib.ugm.ac.id/id/eprint/2402

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