Prognostic Significance of PD-L2 Expression in Association with Neutrophil-to-Lymphocyte Ratio in Urothelial Carcinoma of the Bladder

Hendri, Ahmad Zulfan and Soerohardjo, Indrawarman and Heriyanto, Didik Setyo and Khalilullah, Said Alfin and Dany, Yurisal Akhmad and Danurdoro, Aria (2023) Prognostic Significance of PD-L2 Expression in Association with Neutrophil-to-Lymphocyte Ratio in Urothelial Carcinoma of the Bladder. Asian Pacific Journal of Cancer Prevention, 24 (8). pp. 2673-2679. ISSN 15137368

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Abstract

Background: The prognostic significance of tumoral programmed death-ligand 2 (PD-L2) expression in urothelial bladder cancer (UBCs) is under-investigated, although it can potentially to become a regulatory agent of cancer immunity. In the search for supporting biomarkers, the neutrophil-to-lymphocyte ratio (NLR) as a readily available surrogate marker of immune status has been associated with clinical outcomes and other prognostic factors in various types of cancer. Here we evaluate the prognostic ability of baseline NLR in addition to PD-L2 expression in bladder cancer. Methods: We used a retrospective cohort of UBCs patients from the authors’ institutions. We classified patients according to their PD-L2 and NLR levels. We associated the prognostic outcome of each group with disease-free survival (DFS) and overall survival (OS). Results: Thirty patients had a tumor with positive PD-L2 expression. We found no significant correlation between PD-L2 expression and NLR. PD-L2 status failed to provide a significant prognostic impact (disease-free survival DFS and overall survival OS rate at 5 years, 42.85% in PD-L2-high versus 65.75% in PD-L2-low patients; p = 0.057, 42.85% in PD-L2-high patients versus 62.5% in PD-L2-low patients; p = 0.112, respectively). NLR status also failed to exhibit a significant prognostic impact (DFS and OS rate at 5 years, 44.44% in PD-L2-high versus 66.66% in PD-L2-low patients; p = 0.232, 55.55% in PD-L2-high versus 71.43% in PD-L2-low patients; P = 0.894, respectively). When PD-L2 status and NLR status were combined, the NLR-low and PD-L2-low were significant factors to predict a favorable disease-free survival (hazard ratio, 4.525 95% confidence interval, 1.020 to 20.080; P = 0.047. However, the multivariate analysis failed to show it as an independent factor. Conclusion: These findings suggest that the prognostic impact of PD-L2 expression could be affected by the NLR status. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: Carcinoma, Transitional Cell; Humans; Lymphocytes; Neutrophils; Prognosis; Retrospective Studies; Urinary Bladder; Urinary Bladder Neoplasms; bladder; bladder tumor; human; lymphocyte; neutrophil; prognosis; retrospective study; transitional cell carcinoma
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 19 Jun 2024 07:09
Last Modified: 19 Jun 2024 07:09
URI: https://ir.lib.ugm.ac.id/id/eprint/2547

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