Impact of Gene Polymorphism on Pharmacokinetics and Pharmacodynamics of Calcium Channel Blockers: A Narrative Review

Atmaja, Sarah Puspita and Nugrahaningsih, Dwi Aris Agung and Rawar, Ellsya Angeline and Kristiyani, Ani and Sadewa, Ahmad Hamim and Virginia, Dita Maria (2023) Impact of Gene Polymorphism on Pharmacokinetics and Pharmacodynamics of Calcium Channel Blockers: A Narrative Review. Indonesian Journal of Pharmacy, 34 (3). pp. 372-394. ISSN 23389427

[thumbnail of 434_Sarah  Puspita  Atmaja.pdf] Text
434_Sarah Puspita Atmaja.pdf - Published Version
Restricted to Registered users only
Available under License Creative Commons Attribution.

Download (675kB) | Request a copy

Abstract

A class of drugs known as calcium channel blockers (CCBs) is used to treat hypertension, angina, and arrhythmias. There are two subcategories of this medication class: dihydropyridines and non-dihydropyridines. Studies on CYP3A5*3, AGTR1 rs275653, ABCB1 (MDR1) rs1045642, and POR*28 A503V have all investigated the effects of SNPs on CCBs. In this study, further research will be conducted to determine which SNPs most influence the efficacy of CCBs. The narrative reviews in this article come from a variety of sources. We performed searches in Pubmed, ScienceDirect, and Google Scholar using the terms "calcium channel blocker," "efficacy," "blood pressure response," "pharmacokinetic," and "polymorphism" OR "genetic" OR "genomic" to find relevant articles. When prescribing antihypertensive drugs, especially calcium channel blockers, it is essential to consider specific gene variants, for example, CYP3A5*3/*3, CYP3A4 *1G/*1G, MDR1 C3435T, RyR3 gene rs877087, because of their significant effects.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: calcium channel blocker, gene polymorphism, efficacy
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 05 Jul 2024 01:56
Last Modified: 05 Jul 2024 01:56
URI: https://ir.lib.ugm.ac.id/id/eprint/2767

Actions (login required)

View Item
View Item