Antioxidant and Anti-Arthritic Activities of Green Seaweed Halimeda tuna Methanolic Extract

Gazali, Mohamad and Fatimah, Aden N. and Husni, Amir and Nurjanah, Nurjanah and Zuriat, Zuriat and Syafitri, Rina (2024) Antioxidant and Anti-Arthritic Activities of Green Seaweed Halimeda tuna Methanolic Extract. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 19 (1). pp. 45-54. ISSN 20895690

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Abstract

Seaweed contains various bioactive compounds rich in pharmacological potentials, such as antioxidants and anti-arthritic. This study aims to determine the antioxidant and anti-arthritic activities of the methanolic extract of Halimeda tuna. Halimeda tuna samples were extracted using the maceration method and methanol. The methanol extract was tested for antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP)) and anti-arthritic activity using denatured bovine serum albumin (BSA). The methanol extract was also subjected to phytochemical and Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Research results revealed that the extract yield was 0.50 ± 0.06. Phytochemical analysis showed that H. tuna methanolic extract contained flavonoids, steroids, and alkaloids. GC-MS analysis showed that H. tuna methanolic extract contained steroids, fatty alcohols, and fatty acids. The antioxidant activity tests revealed an IC50 value of 299.98 ± 121.15 ppm and a FRAP value of 200.02 ± 8.50 n M/g, categorized as a weak antioxidant. Anti-arthritic activity of H. tuna methanolic extract showed an IC50 value of 877.29 ± 209.84 ppm. The anti-arthritic activity of H. tuna methanolic extract was lower than sodium diclofenac as a standard drug. The extract of H. tuna has antioxidant and anti-arthritic activities; hence, further exploration is needed as an alternative potential in the pharmacological field.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: himelda tuna, phytochemical, DPPH, FRAP, GC-MS
Subjects: S Agriculture > S Agriculture (General)
Divisions: Faculty of Agriculture > Department of Fisheries
Depositing User: Laili Hidayah Hidayah
Date Deposited: 28 Aug 2024 07:13
Last Modified: 28 Aug 2024 07:13
URI: https://ir.lib.ugm.ac.id/id/eprint/3473

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