Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients

Rachmanadi, Muhammad Berian and Ismail, Muhamad Taufik and Anggraeni, Vita Yanti (2021) Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients. International Journal of Angiology, 30 (4). 257 – 261. ISSN 10611711

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Abstract

The prevalence of diabetes mellitus continues to increase from year to year. Critical limb ischemia (CLI) is one of the complications of diabetes mellitus with a high mortality rate and requires amputation if not treated properly. Mean platelet volume (MPV) is an indicator of platelet activation and is expected to be a predictor of CLI in diabetes mellitus patients.This article investigates the relationship between MPV and the incidence of CLI in diabetes mellitus patients.This case-control study was conducted using the vascular registry of Dr. Sardjito Hospital, Yogyakarta, Indonesia, from January 2016 to December 2016. The relationship between MPV and the incidence of CLI was analyzed using bivariate and multivariate analysis. There was a significant association between MPV and incidence of CLI in diabetes mellitus patient both on bivariate analysis (p = 0.035) and multivariate analysis (p = 0.029). Diabetes mellitus patients with MPV values of ≥ 9.8 fl had a protective effect to prevent the incidence of CLI (bivariate analysis: odds ratio OR = 0.366, 95% confidence interval CI = 0.142-0.943; multivariate analysis: adjusted OR = 0.288, 95% CI = 0.09-0.88). Confounding factors such as sex, age, obesity, and use of antiplatelet agents were not associated with the incidence of CLI (p > 0.05). Meanwhile, history of dyslipidemia as a confounding factor was significantly associated with the incidence of CLI (p < 0.05). Low MPV was found to be significantly associated with the incidence of CLI in diabetes mellitus patients. © 2021 Thieme Medical Publishers, Inc.. All rights reserved.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Green Open Access
Uncontrolled Keywords: acetylsalicylic acid; clopidogrel; adult; Article; bivariate analysis; case control study; clinical evaluation; confounding variable; controlled study; critical limb ischemia; diabetes mellitus; diabetic patient; disease association; dual antiplatelet therapy; dyslipidemia; echography; female; human; human cell; incidence; major clinical study; male; mean platelet volume; medical history; middle aged; multivariate analysis; obesity; observational study; population
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 27 Sep 2024 06:06
Last Modified: 27 Sep 2024 06:06
URI: https://ir.lib.ugm.ac.id/id/eprint/4526

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