ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer

Karsono, Ramadhan and Haryono, Samuel J. and Karsono, Bambang and Harahap, Wirsma Arif and Pratiwi, Yulia and Aryandono, Teguh (2021) ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer. BMC Cancer, 21 (1). ISSN 14712407

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Abstract

Background: The ESR1 gene encodes Estrogen Receptor alpha (ERα), which plays a role in the tumourigenesis of breast cancer. A single nucleotide polymorphism (SNP) in intron 1 of this gene called ESR1 PvuII (rs2234693) has been reported to increase the risk of breast cancer. This study aimed to investigate the ESR1 PvuII polymorphism as a prognostic and predictive factor guiding the choice of therapy for advanced breast cancer. Methods: This retrospective study was conducted in 104 advanced breast cancer patients at Dharmais Cancer Hospital from 2011 to 2018. The ESR1 PvuII polymorphism was analysed by Sanger sequencing of DNA from primary breast tumour samples. Results: The percentages of patients with ESR1 PvuII genotypes TT, TC, and CC were 42.3, 39.4, and 18.3, respectively. Looking at prognosis, patients with ESR1 PvuII TC + CC had shorter overall survival than those with the TT genotype HR = 1.79; 95% CI 1.05–3.04; p = 0.032. As a predictive marker, TC + CC was associated with shorter survival (p = 0.041), but TC + CC patients on primary hormonal therapy had a median overall survival longer than TC + CC patients on primary chemotherapy (1072 vs 599 days). Conclusion: The ESR1 PvuII TC + CC genotypes confer poor prognosis in advanced breast cancer, but these genotypes could be regarded as a good predictor of the therapeutic effect of hormonal treatment. © 2021, The Author(s).

Item Type: Article
Additional Information: Cited by: 2; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Adult; Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Biopsy; Breast; Breast Neoplasms; DNA Mutational Analysis; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Young Adult; anastrozole; aromatase inhibitor; cyclophosphamide; cytosine; DNA; doxorubicin; exemestane; fluorouracil; gonadorelin derivative; letrozole; tamoxifen; thymine; antineoplastic hormone agonists and antagonists; ESR1 protein, human; estrogen receptor alpha; tumor marker; adult; aged; Article; breast cancer; cancer chemotherapy; cancer hormone therapy; cancer patient; cancer prognosis; controlled study; ESR1 gene; female; gene; genotype; human; Indonesia; major clinical study; multiple cycle treatment; overall survival; retrospective study; risk factor; Sanger sequencing; single nucleotide polymorphism; systemic therapy; biopsy; breast; breast tumor; dna mutational analysis; drug resistance; genetic predisposition; genetics; Kaplan Meier method; middle aged; mortality; pathology; prognosis; restriction fragment length polymorphism; risk assessment; risk factor; single nucleotide polymorphism; young adult
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 27 Sep 2024 03:47
Last Modified: 27 Sep 2024 03:47
URI: https://ir.lib.ugm.ac.id/id/eprint/4536

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