Puspitasari, Ika and Susidarti, Ratna Asmah and Nurrochmad, Arief and Pridiyanto, Pridiyanto and Utami, Devie Amalia and Febrian, Pipit and Ziyad, Thoriq (2021) Acute and sub-chronic toxicity study of 1-(2, 5-dihidroxyphenil)-3-pyridine-2-Il-propenone in adult female mice. Indonesian Journal of Pharmacy, 32 (2). 150 – 157. ISSN 23389427
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This research aimed to evaluate the toxicity of 1-(2, 5-dihidroxyphenil)-3-pyridine-2-il-propenone (DPP) after 24h and 90-day administration in female mice. Acute toxicity test was performed using the OECD 423 method, and DPP was administered once a day at doses of 300, 2000, and 5000 mg/kg body weight (BW). Toxic symptoms were observed after 24h of administration and continued until the 14th day. The experimental animals were dissected and examined for histological organs on the 15th day. The sub-chronic toxicity test was performed using the OECD 408 method, and DPP at 14, 28, and 56 mg/kg/day was administered for 90 days. Toxic symptoms were observed every day, and the amount of food and water intakes were also measured. Furthermore, statistical analysis was performed, and changes in body weight, as well as routine blood checks and biochemistry, were observed. At the end of the study, experimental animals were sacrificed, and the vital organs' weights were examined before the histological analysis. The results showed that DPP at 300-5000 mg/kg/day and 14-56 mg/kg/day for 90 days did not show any toxic symptoms respectively. In the sub-chronic toxicity test, no change was observed in blood and urine biochemical parameters (p≥0.05). However, lymphocytic infiltration in the liver and congested vessel in the kidney occurred after administration at 56 mg/kg/day. The results showed that the acute toxicity of DPP is at category 5 according to Globally Harmonized Classification System and sub-chronic toxicity is at a dose below 56 mg/kg/day. Copyright © 2020 The Author(S).
Item Type: | Article |
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Additional Information: | Cited by: 0; All Open Access, Gold Open Access |
Uncontrolled Keywords: | 1 (2,5 dihidroxyphenil) 3 pyridine 2 il propenone; chalcone; pyridine; unclassified drug; acute toxicity; adult; animal experiment; animal model; animal tissue; Article; behavior assessment; biochemical analysis; biochemistry; blood analysis; body weight; chronic toxicity; controlled study; evaluation study; female; fluid intake; food intake; histology; histopathology; lymphocytic infiltration; mouse; nonhuman; organ weight; symptom assessment; toxicity testing |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Pharmacy |
Depositing User: | Sri JUNANDI |
Date Deposited: | 27 Sep 2024 03:13 |
Last Modified: | 27 Sep 2024 03:13 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4552 |