Karsono, Ramadhan and Azhar, Muhammad Al and Pratiwi, Yulia and Saputra, Fahreza and Nadliroh, Siti and Aryandono, Teguh (2021) Effect of Primary Systemic Therapy on PD-1, PD-L1, and PD-L2 mRNA Expression in Advanced Breast Cancer. Asian Pacific Journal of Cancer Prevention, 22 (7). 2069 – 2077. ISSN 15137368
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Objective: The association between PD-1, PD-L1, and PD-L2 expression and prognosis has been extensively studied in various cancers but remained controversial in breast cancer. Besides, little is known about the prognostic value of PD-1, PD-L1, and PD-L2 upregulation or downregulation following systemic therapy (chemotherapy and hormonal therapy) in breast cancer. Therefore, we aim to investigate the change of PD-1, PD-L1, and PD-L2 expression in mRNA level after primary systemic therapy in breast cancer patients and its clinical implications. Methods: Expression of PD-1, PD-L1, and PD-L2 mRNA were measured before-after chemotherapy and hormonal therapy with real-time PCR in 80 advanced breast cancer patients. The correlation between alteration of PD-1, PD-L1, and PD-L2 expression and clinicopathological characteristics as well as overall survival was also statistically analyzed. Results: Chemotherapy and hormonal therapy altered PD-1, PD-L1, and PD-L2 expression in breast cancer with most patients have an increase expression. As much as 57.1, 62.9 and 60 patients have an increase PD-1, PD-L1, and PD-L2 expression after chemotherapy, while 60, 60, and 64 patients have an increase PD-1, PD-L1, and PD-L2 expression after hormonal therapy. Alteration of PD-1, PD-L1, and PD-L2 expression was not correlated with all clinicopathological characteristics. Increase in PD-1, PD-L1, and PD-L2 expression was significantly associated with better OS (p=0.031, p=0.019, and p=0.019 for PD-1, PD-L1, and PD-L2, respectively), which remained significant in multivariate analysis including age, stage, primary systemic therapy, histology grade, subtype and primary tumor histology (HR PD-1 0.5 (95 CI 0.28-0.88) p=0.031; HR PD-L1 0.43 (95 CI 0.24-0.8) p=0.019; HR PD-L2 (95 CI 0.24-0.87) p=0.019). Conclusion: Expression of PD-1, PD-L1, and PD-L2 in breast cancer patients is mostly enhanced after chemotherapy and hormonal therapy, and the enhancement is associated with good OS. This result revealed the potential of measuring PD-1, PD-L1, and PD-L2 mRNA expression in predicting clinical outcome. © 2021. All rights reserved.
Item Type: | Article |
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Additional Information: | Cited by: 2; All Open Access, Gold Open Access, Green Open Access |
Uncontrolled Keywords: | Adult; B7-H1 Antigen; Breast Neoplasms; Female; Humans; Middle Aged; Prognosis; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; RNA, Messenger; CD274 protein, human; messenger RNA; programmed death 1 ligand 1; programmed death 1 ligand 2; programmed death 1 receptor; adult; breast tumor; female; human; metabolism; middle aged; pathology; prognosis |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Biomedical Sciences |
Depositing User: | Sri JUNANDI |
Date Deposited: | 27 Sep 2024 02:29 |
Last Modified: | 27 Sep 2024 02:29 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4584 |