Serum endothelin-1 level positively correlates with waist and hip circumferences in stable coronary artery disease patients

Hartopo, Anggoro Budi and Fachiroh, Jajah and Puspitawati, Ira and Dewi, Fatwa Sari Tetra (2021) Serum endothelin-1 level positively correlates with waist and hip circumferences in stable coronary artery disease patients. Reviews in Cardiovascular Medicine, 22 (3). 919 – 924. ISSN 15306550

Full text not available from this repository. (Request a copy)

Abstract

Central obesity is associated with increased level and activity of endothelin-1. The waist and hip circumferences are simple indicators of central obesity. Waist circumference correlates with visceral adiposity, whereas hip circumference associates with gluteofemoral peripheral adiposity. Both measurements have independent and opposite correlation with coronary artery disease (CAD) risk factors. The relation between serum endothelin-1 in stable CAD and both parameters of central obesityneeds to be investigated. This study aims to examine the correlation between serum endothelin-1 level and waist and hip circumferences as parameters of central obesity in patients with stable CAD. This was a cross-sectional study. Consecutive subjects were enrolled among those who underwent elective coronary angiography with significant CAD. Serum endothelin-1 was measured from peripheral blood samples taken before coronary angiography procedure. The measurement of waist circumference, hip circumference, and ratio derived from them, was performed. Central obesity was determined by waist circumference cut-off for Indonesian population. The correlation analysis was performed with Pearson test. The multivariate analysis was performed with multiple linear regression test. The comparison of serum endothelin-1 level between groups was performed with Student T test. We enrolled 50 subjects. The majority of subjects was male (80.0), hypertensive (86.0), dyslipidemic (68) and smoker (52). Most subjects had history of acute coronary syndrome (64). Mean waist circumference was 87.6 +/- SD cm, hip circumference was 95.3 cm +/- SD, mean waist-to-hip ratio was 0.92 +/- SD and mean waist-to-height ratio was 0.54 +/- SD. Central obesity occurred in 32 of subjects. Mean serum endothelin-1 level was 2.2 ± 0.7 pg/mL. Serum endothelin-1 level tended to be higher in subjects with central obesity as compared to those without. Serum endothelin-1 level was significantly correlated with age, hemoglobin level, waist circumference (coefficient of 0.311, p value = 0.023) and hip circumference (coefficient of 0.359, p value = 0.010). Multivariable analysis indicated that age (coefficient of -0.353, p value = 0.007) and hip circumference (coefficient of 0.335, p value = 0.011) were independently correlated with serum endothelin-1. For conclusion, in patients with stable CAD, serum endothelin-1 was positively correlated with both waist circumference and hip circumference. Hip circumference independently and positively correlated with serum endothelin-1 level. © 2021 The Author(s). Published by IMR Press.

Item Type: Article
Additional Information: Cited by: 4; All Open Access, Gold Open Access
Uncontrolled Keywords: Body Mass Index; Coronary Artery Disease; Cross-Sectional Studies; Endothelin-1; Humans; Male; Risk Factors; Waist Circumference; endothelin 1; hemoglobin; endothelin 1; acute coronary syndrome; adult; Article; blood sampling; clinical article; coronary angiography; coronary artery disease; correlational study; dyslipidemia; female; groups by age; hemoglobin blood level; hip circumference; human; hypertension; male; middle aged; obesity; protein blood level; smoking; waist circumference; waist hip ratio; waist to height ratio; body mass; coronary artery disease; cross-sectional study; diagnostic imaging; risk factor; waist circumference
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 27 Sep 2024 00:47
Last Modified: 27 Sep 2024 00:47
URI: https://ir.lib.ugm.ac.id/id/eprint/4587

Actions (login required)

View Item
View Item