The Effect of Sonication Time for Synthesis of Magnetic Mesoporous Nanosilica using Cetyltrimethylammonium Bromide (CTAB) as Surfactant-Template

Targeted drug delivery systems with nanomaterials as drug carriers to specific organs canincrease the therapeutic effect and reduce the side effects. Magnetic mesoporous silica nanoparticle sare a multifunctional platform in drug delivery and magnetic hyperthermia therapy. In this study, the synthesis was developed with iron sand from Glagah Beach as a source for the magnetic nanoparticles source and CTAB as a surfactant template. The research method was carried out in three steps, including the synthesis of magnetic nanoparticles (Fe3O4), coating of magnetic nanoparticles(Fe3O4@SiO2), and surfactant-templating (Fe3O4@SiO2@CTAB/SiO2). The SEM analysis resultsshowed that the Fe3O4 particles have various sizes. The weight concentration of Fe in Fe3O4 increasedfrom 70.25% to 78.58% compared to Fe in iron sand by EDX analysis. The XRD results showed thatthe crystalline size of Fe3O4 and Fe3O4@SiO2 particles are 6.31 and 2.37 nm, respectively. From theresults of BET analysis, it is known that the longer the sonication time, the pore diameter tends todecrease. It may be due to CTAB filling in the pore during the surfactant-templating process. Thehighest surface area of the Fe3O4@SiO2@CTAB/SiO2 particle obtained was 14.31 m2/g with a porediameter of 3.915 nm which has a mesoporous structure