Identification and quantification of metamizole in traditional herbal medicines using spectroscopy ftir-atr combined with chemometrics

Fatmarahmi, Dharmastuti Cahya and Susidarti, Ratna Asmah and Swasono, Respati Tri and Rohman, Abdul (2021) Identification and quantification of metamizole in traditional herbal medicines using spectroscopy ftir-atr combined with chemometrics. Research Journal of Pharmacy and Technology, 14 (8). 4413 – 4419. ISSN 09743618

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Abstract

The study aims to develop an effective, efficient, and reliable method using Fourier Transform Infrared (FTIR) spectroscopy with Attenuated Total Reflection (ATR) combined with chemometric for identifying the synthetic drug in Indonesian herbal medicine known as Jamu. Jamu powders, Metamizole, and the binary mixture of Jamu and Metamizole were measured using FTIR-ATR at the mid-infrared region (4000-650 cm-1). The obtained spectra profiles were further analyzed by Principal Component Analysis, Partial Least Square Regression, Principal Component Regression, and Discriminant Analysis. Jamu Pegel Linu (JPL), Jamu Encok (JE), Jamu Sakit Pinggang (JSP), Metamizole (M), and adulterated Jamu by Metamizole were discriminated well on PCA score plot. PLSR and PCR showed the accuracy and precision data to quantify JPL, JE, and JSP, and each adulterated by M with R2 value > 0,995 and low value of RMSEC and RMSEP. Discriminant Analysis (DA) was successfully grouping Jamu and Metamizole without any misclassification. A combination of FTIR spectroscopy and chemometrics offered useful tools for detecting Metamizole in traditional herbal medicine. © RJPT All right reserved.

Item Type: Article
Additional Information: Cited by: 8
Uncontrolled Keywords: dipyrone; herbaceous agent; jamu powder; unclassified drug; Article; attenuated total reflectance Fourier transform infrared spectroscopy; chemometrics; controlled study; discriminant analysis; drug mixture; herbal medicine; nonhuman; principal component analysis
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 25 Sep 2024 04:59
Last Modified: 25 Sep 2024 04:59
URI: https://ir.lib.ugm.ac.id/id/eprint/4631

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