Roles of micrornas in regulating cancer stemness in head and neck cancers

Fitriana, Melysa and Hwang, Wei-Lun and Chan, Pak-Yue and Hsueh, Tai-Yuan and Liao, Tsai-Tsen (2021) Roles of micrornas in regulating cancer stemness in head and neck cancers. Cancers, 13 (7). ISSN 20726694

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Abstract

Head and neck squamous cell carcinomas (HNSCCs) are epithelial malignancies with 5-year overall survival rates of approximately 40–50. Emerging evidence indicates that a small population of cells in HNSCC patients, named cancer stem cells (CSCs), play vital roles in the processes of tumor initiation, progression, metastasis, immune evasion, chemo-/radioresistance, and recur-rence. The acquisition of stem-like properties of cancer cells further provides cellular plasticity for stress adaptation and contributes to therapeutic resistance, resulting in a worse clinical outcome. Thus, targeting cancer stemness is fundamental for cancer treatment. MicroRNAs (miRNAs) are known to regulate stem cell features in the development and tissue regeneration through a miRNA– target interactive network. In HNSCCs, miRNAs act as tumor suppressors and/or oncogenes to modulate cancer stemness and therapeutic efficacy by regulating the CSC-specific tumor microen-vironment (TME) and signaling pathways, such as epithelial-to-mesenchymal transition (EMT), Wnt/β-catenin signaling, and epidermal growth factor receptor (EGFR) or insulin-like growth factor 1 receptor (IGF1R) signaling pathways. Owing to a deeper understanding of disease-relevant miR-NAs and advances in in vivo delivery systems, the administration of miRNA-based therapeutics is feasible and safe in humans, with encouraging efficacy results in early-phase clinical trials. In this review, we summarize the present findings to better understand the mechanical actions of miRNAs in maintaining CSCs and acquiring the stem-like features of cancer cells during HNSCC pathogenesis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Additional Information: Cited by: 9; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: beta catenin; epidermal growth factor receptor; microRNA; somatomedin C; somatomedin C receptor; cancer growth; cancer inhibition; cancer recurrence; cancer stem cell; cancer stemness; cell plasticity; cell self-renewal; clinical outcome; epithelial mesenchymal transition; gene product; head and neck squamous cell carcinoma; heredity; human; immune evasion; in vivo study; let-7a gene; let-7c gene; let-7d gene; let-7i gene; metastasis; miR-101 gene; miR-106A- 5p gene; miR-107 gene; miR-124 gene; miR-1246 gene; miR-125a gene; miR-134 gene; miR-139-5p gene; miR-196b gene; miR-19a gene; miR-203 gene; miR-204-5p gene; miR-29b gene; miR-365-3p gene; miR-424 gene; miR-495 gene; miR-520b gene; miR-629-3p gene; miR-9 gene; miR-98 gene; molecular mechanics; nonhuman; oncogene; pathogenesis; Review; signal transduction; tissue regeneration; tumor microenvironment; Wnt signaling
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 25 Sep 2024 05:38
Last Modified: 25 Sep 2024 05:38
URI: https://ir.lib.ugm.ac.id/id/eprint/4667

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