Seven-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one reduces atherogenic index and Nrf2 and GPx gene expressions in hyperlipidemic rats

Prasetyastuti, Prasetyastuti and Ayunda, Rahmah Dara and Sunarti, Sunarti (2021) Seven-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one reduces atherogenic index and Nrf2 and GPx gene expressions in hyperlipidemic rats. Tropical Journal of Pharmaceutical Research, 18 (6). 1173 – 1177. ISSN 15965996

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Abstract

Purpose: To investigate the effect of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one isolated from mahogany (Swietenia macrophylla King) seeds on atherogenic index, expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and expression of the glutathione peroxidase (GPx) genes in hyperlipidemic rats. Methods: A total of 25 rats male aged 8 weeks and weighing an average of 200 g were used. They were divided into five groups as follows: (I) normal (N), (II) hyperlipidemic (HL), (III) hyperlipidemic rats treated with simvastatin (HL+SV), (IV and V) hyperlipidemic rats treated with 30 or 90mg, respectively, of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one per 200 g body weight per day for 4 weeks. Atherogenic index (AI) was calculated from the levels of triglyceride (TG) and high-density lipoprotein (HDL) while Nrf2 and GPx gene expressions were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Two different doses of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one in hyperlipidemic rats significantly reduced their atherogenic index (p < 0.05). Nrf2 and GPx expression levels were lower than (p > 0.05) those of hyperlipidemic group. Conclusion: Seven-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one reduces the atherogenic index and expression levels of Nrf2 and GPx genes in hyperlipidemic rats. Thus, this compound has potential as an antihyperlipidemic agent. © 2019 The authors.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: 7 hydroxy 2 (4 hydroxy 3 methoxyphenyl) chromen 4 one; antilipemic agent; chromone derivative; glutathione peroxidase; high density lipoprotein; high density lipoprotein cholesterol; low density lipoprotein cholesterol; malonaldehyde; simvastatin; transcription factor Nrf2; triacylglycerol; unclassified drug; animal experiment; animal model; animal tissue; Article; atherogenic index; controlled study; gene expression; hyperlipidemia; male; nonhuman; oxidative stress; protein expression; rat; real time polymerase chain reaction; triacylglycerol blood level
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 25 Sep 2024 04:05
Last Modified: 25 Sep 2024 04:05
URI: https://ir.lib.ugm.ac.id/id/eprint/4680

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