Muhammad, Harry Freitag Luglio and Sulistyoningrum, Dian Caturini and Huriyati, Emy and Lee, Yi Yi and Muda, Wan Abdul Manan Wan (2021) The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: An Indonesian Nutrigenetic Cohort (INDOGENIC). British Journal of Nutrition, 125 (6). 611 – 617. ISSN 00071145
Full text not available from this repository. (Request a copy)Abstract
The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β = 0·128, P = 0·023) and body fat (β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β = 0·232, P = 0·016) and body fat (β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating. ©
Item Type: | Article |
---|---|
Additional Information: | Cited by: 4 |
Uncontrolled Keywords: | Adipose Tissue; Adiposity; Adult; Alleles; Body Weight; Energy Intake; Exercise; Female; Genetic Variation; Genotype; Humans; Indonesia; Male; Middle Aged; Nutrigenomics; Prospective Studies; Uncoupling Protein 2; Young Adult; uncoupling protein 2; UCP2 protein, human; uncoupling protein 2; adult; Article; body fat; body mass; body weight change; body weight gain; caloric intake; cohort analysis; energy metabolism; female; gene function; genetic variation; genotype; human; lifestyle; male; obesity; physical activity; prospective study; UCP2 gene; adipose tissue; allele; body weight; exercise; genetics; Indonesia; middle aged; nutrigenomics; young adult |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition |
Depositing User: | Sri JUNANDI |
Date Deposited: | 25 Sep 2024 01:07 |
Last Modified: | 25 Sep 2024 01:07 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4690 |