The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: An Indonesian Nutrigenetic Cohort (INDOGENIC)

Muhammad, Harry Freitag Luglio and Sulistyoningrum, Dian Caturini and Huriyati, Emy and Lee, Yi Yi and Muda, Wan Abdul Manan Wan (2021) The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: An Indonesian Nutrigenetic Cohort (INDOGENIC). British Journal of Nutrition, 125 (6). 611 – 617. ISSN 00071145

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Abstract

The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β = 0·128, P = 0·023) and body fat (β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β = 0·232, P = 0·016) and body fat (β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating. ©

Item Type: Article
Additional Information: Cited by: 4
Uncontrolled Keywords: Adipose Tissue; Adiposity; Adult; Alleles; Body Weight; Energy Intake; Exercise; Female; Genetic Variation; Genotype; Humans; Indonesia; Male; Middle Aged; Nutrigenomics; Prospective Studies; Uncoupling Protein 2; Young Adult; uncoupling protein 2; UCP2 protein, human; uncoupling protein 2; adult; Article; body fat; body mass; body weight change; body weight gain; caloric intake; cohort analysis; energy metabolism; female; gene function; genetic variation; genotype; human; lifestyle; male; obesity; physical activity; prospective study; UCP2 gene; adipose tissue; allele; body weight; exercise; genetics; Indonesia; middle aged; nutrigenomics; young adult
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 25 Sep 2024 01:07
Last Modified: 25 Sep 2024 01:07
URI: https://ir.lib.ugm.ac.id/id/eprint/4690

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