Treatment Outcome of Children with Retinoblastoma in a Tertiary Care Referral Hospital in Indonesia

Handayani, Krisna and Indraswari, Braghmandita W and Sitaresmi, Mei N and Mulatsih, Sri and Widjajanta, Pudjo H and Kors, Wijnanda A and Kaspers, Gertjan Jl and Mostert, Saskia (2021) Treatment Outcome of Children with Retinoblastoma in a Tertiary Care Referral Hospital in Indonesia. Asian Pacific Journal of Cancer Prevention, 22 (5). 1613 – 1621. ISSN 15137368

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Abstract

Background: Although survival rates for retinoblastoma (RB) are over 95 in high-income countries, its high mortality rate in low and middle-income countries remains a great concern. Few studies investigated treatment outcome and factors contributing to RB survival in these latter settings. Aims of this study are to determine treatment outcome of Indonesian children diagnosed with RB and to explore factors predictive of treatment outcome. Methods: This study was a retrospective medical records review combined with an illustrative case report. Children newly diagnosed with RB between January 2011 and December 2016 at a tertiary care referral hospital in Indonesia were included. A home visit was conducted to perform an in-depth interview with a mother of two children affected by RB. Results: Of all 61 children with RB, 39 abandoned treatment, 21 died, 20 had progressive or relapsed disease and 20 event-free survival. Progressive or relapsed disease was more common in older (2 years at diagnosis, 29) than young (<2 years at diagnosis, 0) children (P=0.012). Event-free survival estimate at 5 years was higher in young (42) than older (6) children (P=0.045). Odds-ratio for event-free survival was 6.9 (95 CI: 1.747 - 27.328, P=0.006) for young versus older children. Other clinical and socio-demographic characteristics had no significant correlation with treatment outcome or event-free survival. The case report elucidated conditions and obstacles that Indonesian families face when their children are diagnosed with RB. Conclusion: Survival of children with RB in Indonesia is much lower compared to high-income and many other low and middle-income countries. Abandonment of treatment is the most common cause of treatment failure. Older age at diagnosis is associated with more progressive or relapsed disease and worse survival. Interventions to improve general public and health-care providers' awareness, early detection and treatment adherence are required. © 2021. All Rights Reserved.

Item Type: Article
Additional Information: Cited by: 4; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Eye Enucleation; Female; Follow-Up Studies; Humans; Indonesia; Infant; Infant, Newborn; Male; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Survival Rate; Tertiary Healthcare; Treatment Outcome; antineoplastic agent; adolescent; child; eye enucleation; female; follow up; human; Indonesia; infant; male; mortality; multimodality cancer therapy; newborn; pathology; preschool child; retina tumor; retinoblastoma; retrospective study; survival rate; tertiary health care; treatment outcome
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 25 Sep 2024 00:22
Last Modified: 25 Sep 2024 00:22
URI: https://ir.lib.ugm.ac.id/id/eprint/4696

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