Wibowo, Tunjung and Nurani, Neti and Hastuti, Janatin and Anggraini, Alifah and Susilowati, Rina and Hakimi, Mohammad and Julia, Madarina and Van Weissenbruch, Mirjam (2021) Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns. Frontiers in Pediatrics, 9. ISSN 22962360
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Background: Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life. Objectives: To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns. Subjects/Methods: A cross-sectional study was conducted in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. A total of 45 term, appropriate for gestational age (AGA) newborns were included in this study. BMC was assessed by dual-energy x-ray absorptiometry (DXA) in the first week of life. Weight (g), length (cm) and head circumference (cm) were measured at birth. Data on maternal characteristics were obtained from the maternal health records or reported by the mothers. Results: WB BMC measured in the present study (mean ± SD: 33.2 ± 9.3 g) was lower than WB BMC of similar populations in developed countries. Multiple linear regression showed that birth weight, birth length, and gestational age had a positive association with WB BMC (p = 0.048, 0.017, and <0.001, respectively), while maternal cigarette exposure had a negative association with WB BMC (p = 0.012). Male infants had significantly higher of WB BMC than female (p = 0.025). These determinants contribute to 55 variability of WB BMC. Conclusions: WB BMC in Indonesian term newborns is lower than populations in developed countries. Birth weight, length, gestational age, sex, and maternal cigarette exposure during pregnancy are significantly associated with WB BMC observed in Indonesian newborns. © Copyright © 2021 Wibowo, Nurani, Hastuti, Anggraini, Susilowati, Hakimi, Julia and Van Weissenbruch.
Item Type: | Article |
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Additional Information: | Cited by: 2; All Open Access, Gold Open Access, Green Open Access |
Uncontrolled Keywords: | adult; Article; body height; body weight; bone mineral; controlled study; cross-sectional study; developed country; dual energy X ray absorptiometry; female; gestational age; head circumference; Indonesia; Indonesian; male; maternal welfare; mother; newborn; nonhuman; sex difference |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition |
Depositing User: | Sri JUNANDI |
Date Deposited: | 24 Sep 2024 07:28 |
Last Modified: | 24 Sep 2024 07:28 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4710 |