The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis

Fahmi, Moh Nailul and Hertapanndika, Inge Nandya and Kusuma, Fitriyadi (2021) The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis. Asian Pacific Journal of Cancer Prevention, 22 (12). 4057 – 4065. ISSN 15137368

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Abstract

Objectives: Prognostic biomarkers in cervical cancer are widely investigated, including cancer stem cell (CSC) markers. However, their significance remains uncertain. This study aimed to determine the role of cervical cancer stem cell (CCSC) markers for survival. Materials and Methods: We conducted a systematic review and meta-analysis (PROSPERO CRD42021237072) of studies reporting CCSC markers as the prognostic predictor based on PRISMA guidelines. We included English articles investigating associations of CCSCs expression in tissue tumor with overall survival (OS) or disease-free survival (DFS) from PubMed, EBSCO, and The Cochrane Library databases. The quality of studies was analyzed based on Newcastle-Ottawa Quality Assessment Scale. Results: From 413 publications, after study selection with inclusion and exclusion criteria, 22 studies were included. High expressions of CCSC markers were associated with poor OS and DFS (HR= 1.05, 95 CI: 1.03 – 1.07, P <0.0001; HR= 1.31, 95 CI: 1.09 – 1.17, P <0.00001; respectively). Sub-analysis of individual CCSC markers indicated significant correlations between CD44 (HR= 1.14, 95 CI: 1.07 – 1.22, P 0.0001), SOX2 (HR= 1.58, 95 CI: 1.17 – 2.14, P 0.003), OCT4 (HR= 1.03, 95 CI: 1.01 – 1.06, P 0.008), ALDH1 (HR= 1.36, 95 CI: 1.13 – 1.64, P 0.001), and CD49f (HR= 3.02, 95 CI: 1.37 – 6.64, P 0.006) with worse OS; OCT4 (HR= 1.14, 95 CI 1.06 – 1.22, P 0.0003), SOX2 (HR= 1.11, 95 CI: 1.06 – 1.16, P <0.0001), and ALDH1 (HR= 1.22, 95 CI: 1.10 – 1.35, P 0.0002) with poor DFS. We did not conduct a meta-analysis for MSI-1 and CK17 because only one study investigated those markers. Conclusion: Expressions of OCT4, SOX2, and ALDH1 were associated with poor OS and DFS in cervical cancer tissue. These markers might have potential roles as prognostic biomarkers to predict unfavorable survival © 2021. Asian Pacific Journal of Cancer Prevention.All Rights Reserved

Item Type: Article
Additional Information: Cited by: 11; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Aldehyde Dehydrogenase 1 Family; Biomarkers, Tumor; Disease-Free Survival; Female; Humans; Hyaluronan Receptors; Neoplastic Stem Cells; Octamer Transcription Factor-3; Predictive Value of Tests; Prognosis; SOXB1 Transcription Factors; Uterine Cervical Neoplasms; CD44 protein, human; hyaluronic acid binding protein; octamer transcription factor 4; POU5F1 protein, human; SOX2 protein, human; transcription factor Sox; tumor marker; cancer stem cell; disease free survival; female; genetics; human; meta analysis; metabolism; mortality; predictive value; prognosis; uterine cervix tumor
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 24 Sep 2024 02:10
Last Modified: 24 Sep 2024 02:10
URI: https://ir.lib.ugm.ac.id/id/eprint/4739

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