Ethanolic Extract of Pluchea indica Less Leaf Increases Serum Growth Hormone in Lactating Rats

Syarif, Rul Afiyah and Anggorowati, Nungki and Yuniyanti, Mia Munawaroh and Wahyuningsih, Mae Sri Hartati (2021) Ethanolic Extract of Pluchea indica Less Leaf Increases Serum Growth Hormone in Lactating Rats. Majalah Obat Tradisional, 26 (2). 111 – 116. ISSN 14105918

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Abstract

The objectives of the study were to evaluate the effect of ethanolic extract of P. indica Less leaf (EPI) on serum growth hormone (GH), milk yield, body weight gain of dams, and dam’s organ weight in lactating rats. A total of 25 lactating rats with six pups were randomized and distributed to one of five treatments (control (RO water), standard (domperidone 2,5 mg/kg BW/day), EPI 250 (250 mg/kg BW of EPI), EPI 500 (500 mg/kg BW of EPI), and EPI 750 (750 mg/kg BW of EPI)). The treatment was administered daily starting from the 2nd until the 15th day of lactation. On the 16th day serum growth hormone level, body and organ weight of rats were measured. Serum GH levels in the EPI 750 group (1963.25 ± 360.91 pg/µL) increased significantly compared to the domperidone (409.46 ± 28.80 pg/µL) and the control group (723.40 ± 95.78 pg/µL, p<0.05). The total milk yield in the EPI 750 group was not significantly higher when compared to the control group (p>0.05). There was significant body weight gain in the EPI 750 group compared with the domperidone group. There was no significant difference in organ weight gain in each group. The study revealed that ethanolic extract of P. indica Less leaf can increase serum growth hormone in lactating rats. © 2021, Universitas Gadjah Mada - Faculty of Pharmacy. All rights reserved.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: Pluchea indica; growth hormone; milk production; body weight
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 24 Sep 2024 02:15
Last Modified: 24 Sep 2024 02:15
URI: https://ir.lib.ugm.ac.id/id/eprint/4741

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