The molecular mechanisms of hypoglycemic properties and safety profiles of swietenia macrophylla seeds extract: A review

Yudhani, Ratih Dewi and Nugrahaningsih, Dwi Aris Agung and Sholikhah, Eti Nurwening and Mustofa, Mustofa (2021) The molecular mechanisms of hypoglycemic properties and safety profiles of swietenia macrophylla seeds extract: A review. Open Access Macedonian Journal of Medical Sciences, 9. 370 – 388. ISSN 18579655

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Abstract

BACKGROUND: Insulin resistance (IR) is known as the root cause of type 2 diabetes; hence, it is a substantial therapeutic target. Nowadays, studies have shifted the focus to natural ingredients that have been utilized as a traditional diabetes treatment, including Swietenia macrophylla. Accumulating evidence supports the hypoglycemic activities of S. macrophylla seeds extract, although its molecular mechanisms have yet to be well-established. AIM: This review focuses on the hypoglycemic molecular mechanisms of S. macrophylla seeds extract and its safety profiles. METHODS: An extensive search of the latest literature was conducted from four main databases (PubMed, Scopus, Science Direct, and Google Scholar) using several keywords: “swietenia macrophylla, seeds, and diabetes;” “swietenia macrophylla, seeds, and oxidative stress;” “swietenia macrophylla, seeds, and inflammation;” “swietenia macrophylla, seeds, and GLUT4;” and “swietenia macrophylla, seeds, and toxicities.” RESULTS: The hypoglycemic activities occur through modulating several pathways associated with IR and T2D pathogenesis. The seeds extract of S. macrophylla modulates oxidative stress by decreasing malondialdehyde (MDA), oxidized low-density lipoprotein, and thiobarbituric acid-reactive substances while increasing antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Another propose mechanism is the modulating of the inflammatory pathway by attenuating nuclear factor kappa β, tumor necrosis factor α, inducible nitric oxide synthase, and cyclooxygenase 2. Some studies have shown that the extract can also control phosphatidylinositol-3-kinase/ Akt (PI3K/Akt) pathway by inducing glucose transporter 4, while suppressing phosphoenolpyruvate carboxykinase. Moreover, in vitro cytotoxicity and in vivo toxicity studies supported the safety profile of S. macrophylla seeds extract with the LD50 higher than 2000 mg/kg. CONCLUSION: The potential of S. macrophylla seeds as antidiabetic candidate is supported by many studies that have documented their non-toxic and hypoglycemic effects, which involve several molecular pathways. © 2021 Ratih Dewi Yudhani, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Mustofa Mustofa.

Item Type: Article
Additional Information: Cited by: 5; All Open Access, Gold Open Access
Uncontrolled Keywords: 4 bis (3,4,5 trimethoxy phenyl) tetrahydro furo(3,4 c)furan; 6 o acetylswietenolide; 7 hydroxy 2 (4 hydroxy 3 methoxy phenyl) chroman 4 one; antidiabetic agent; catalase; cyclooxygenase 2; diacetyl swietenolide; glucose transporter 4; glutathione peroxidase; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; malonaldehyde; oxidized low density lipoprotein; peroxisome proliferator activated receptor gamma; phosphoenolpyruvate carboxykinase (GTP); phytochemical; plant extract; superoxide dismutase; Swietenia macrophylla extract; swietenine; thiobarbituric acid reactive substance; tumor necrosis factor; unclassified drug; antidiabetic activity; antioxidant activity; drug cytotoxicity; drug safety; endoplasmic reticulum stress; human; insulin resistance; insulin signaling; LD50; lipotoxicity; MAPK signaling; molecular docking; non insulin dependent diabetes mellitus; oxidative stress; phytochemistry; Pi3K/Akt signaling; Review; unfolded protein response
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 24 Sep 2024 05:42
Last Modified: 24 Sep 2024 05:42
URI: https://ir.lib.ugm.ac.id/id/eprint/4743

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