IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis

Nanda, Josephine Diony and Ho, Tzong-Shiann and Satria, Rahmat Dani and Jhan, Ming-Kai and Wang, Yung-Ting and Lin, Chiou-Feng (2021) IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis. Journal of Immunology Research, 2021. ISSN 23148861

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Abstract

Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin-(IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies. © 2021 Josephine Diony Nanda et al.

Item Type: Article
Additional Information: Cited by: 7; All Open Access, Gold Open Access
Uncontrolled Keywords: Aedes; Animals; Dengue; Dengue Virus; Disease Vectors; Humans; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; interleukin 18; inflammasome; interleukin 18; interleukin 1beta; atherosclerosis; atopic dermatitis; chronic obstructive lung disease; cytokine response; dengue; diabetes mellitus; disease exacerbation; Flavivirus infection; human; immunopathogenesis; malignant neoplasm; nonhuman; Review; Aedes; animal; dengue; Dengue virus; disease carrier; immunology; inflammation; metabolism; physiology
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 23 Sep 2024 03:14
Last Modified: 23 Sep 2024 03:14
URI: https://ir.lib.ugm.ac.id/id/eprint/4781

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