Toxic substance-induced hippocampal neurodegeneration in rodents as model of Alzheimer’s dementia

Nurmasitoh, Titis and Sari, Dwi Cahyani Ratna and Susilowati, Rina (2021) Toxic substance-induced hippocampal neurodegeneration in rodents as model of Alzheimer’s dementia. Open Access Macedonian Journal of Medical Sciences, 9. 523 – 533. ISSN 18579655

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Abstract

BACKGROUND: Alzheimer’s Dementia (AD) cases are increasing with the global elderly population. To study the part of the brain affected by AD, animal models for hippocampal degeneration are still necessary to better understand AD pathogenesis and develop treatment and prevention measures. AIM: This study was a systematic review of toxic substance-induced animal models of AD using the Morris Water Maze method in determining hippocampal-related memory impairment. Our aim was reviewing the methods of AD induction using toxic substances in laboratory rodents and evaluating the report of the AD biomarkers reported in the models. METHODS: Data were obtained from articles in the PubMed database, then compiled, categorized, and analyzed. Eighty studies published in the past 5 years were included for analysis. RESULTS AND DISCUSSION: The most widely used method was intracerebroventricular injection of amyloid-β substances. However, some less technically challenging techniques using oral or intraperitoneal administration of other toxic substances also produce successful models. Instead of hippocampal neurodegeneration, many studies detected biomarkers of the AD pathological process while some reported inflammation, oxidative stress, neurotrophic factors, and changes of cholinergic activity. Female animals were underrepresented despite a high incidence of AD in women. CONCLUSION: Toxic substances may be used to develop AD animal models characterized with appropriate AD pathological markers. Characterization of methods with the most easy-handling techniques and more studies in female animal models should be encouraged. © 2021 Titis Nurmasitoh, Dwi Cahyani Ratna Sari, Rina Susilowati.

Item Type: Article
Additional Information: Cited by: 3; All Open Access, Gold Open Access
Uncontrolled Keywords: acetylcholine; acetylcholinesterase; amyloid beta protein; amyloid precursor protein; beta catenin; biological marker; choline acetyltransferase; dopamine; glutamate sodium; glutathione; glutathione peroxidase; glycogen synthase kinase 3beta; interleukin 1beta; neurotrophic factor; okadaic acid; protein kinase B; streptozocin; tau protein; water; Alzheimer disease; apoptosis; Article; brain cortex; cell differentiation; cerebrovascular accident; enzyme activity; human; incidence; Medline; memory disorder; Morris water maze test; nerve degeneration; nervous system development; neuroprotection; nonhuman; ovary polycystic disease; oxidative stress; polymerase chain reaction; quality control; signal transduction; systematic review; TUNEL assay; Western blotting
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 20 Sep 2024 02:09
Last Modified: 20 Sep 2024 02:09
URI: https://ir.lib.ugm.ac.id/id/eprint/4810

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