Evaluation of Human Leukocyte Antigen Class i and Class II in End-Stage Renal Disease Occurrence in Indonesian Transplantation Patients

Susianti, Hani and Djatmiko, Dwi Priyadi and Adi Widana, I. Komang and Tandio, Deasy Ayuningtyas and Sutrisnani, Catur Suci and Wahono, Singgih Pudjo and Puspitawati, Ira (2021) Evaluation of Human Leukocyte Antigen Class i and Class II in End-Stage Renal Disease Occurrence in Indonesian Transplantation Patients. International Journal of Nephrology, 2021. ISSN 2090214X

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Abstract

Background. Genetic studies of end-stage renal disease (ESRD), including those of human leukocyte antigen (HLA) genes, have been reported in several populations but have not yet been evaluated in Indonesia. Some studies have reported that these genes had a substantial role in ESRD. This study aims to analyze the association between HLA genes and ESRD within the Indonesian community. Method. A retrospective study to investigate HLA class I and II alleles to find out the distribution of HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1 in renal transplant recipients and to ascertain their role in susceptibility to ESRD was performed on totally 149 subjects, consisting of 69 ESRD patients and 80 healthy controls. HLA typing was determined using Luminex techniques. The allele and haplotype frequencies were compared between ESRD patients and controls. Result. High-frequency alleles were HLA-A∗24 (43.6), B∗15 (38.2), C∗08 (30.8), DRB1∗12 (47.3), DQB1∗03 (50.6), and DPB1∗13 (22.5). HLA-A∗24 p=0.01 and HLA-B∗35 p=0.02 were associated with a protective effect, with OR 0.537 (95CI 0.34-0.86) and 0.316 (95CI 0.11-0.88), respectively. There were some two-locus haplotypes associated with susceptibility to ESRD, such as B∗15-DRB1∗12, B∗13-DRB1∗15, A∗02-B∗15, A∗02-C∗08, and B∗13-DQB1∗05. HLA-A∗02-B∗15-DRB1∗12 and A∗24-B∗13-DRB1∗15 appear to be associated with susceptibility to ESRD. Conclusion. The allele groups of HLA-A∗24 and HLA-B∗35 are associated with protection from ESRD. Meanwhile, HLA-B∗13-DRB1∗15 and A∗24-B∗13-DRB1∗15 are the most frequent HLAs associated with ESRD in two-locus and three-locus haplotype, respectively. © 2021 Hani Susianti et al.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: genomic DNA; HLA A antigen; HLA antigen class 1; HLA antigen class 2; HLA B antigen; HLA C antigen; HLA DPB1 antigen; HLA DQB1 antigen; HLA DRB1 antigen; HLA DRB3 antigen; leukocyte antigen; adult; Article; clinical evaluation; community care; comparative study; controlled study; disease association; DNA extraction; end stage renal disease; female; gene frequency; gene sequence; genetic association; genetic susceptibility; graft recipient; haplotype; HLA typing; human; human tissue; Indonesian; kidney graft; major clinical study; male; retrospective study
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 20 Sep 2024 06:15
Last Modified: 20 Sep 2024 06:15
URI: https://ir.lib.ugm.ac.id/id/eprint/4816

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