Predictors of pulmonary hypertension in children with left-to-right shunting in acyanotic congenital heart disease

Inrianto, Weny and Murni, Indah K. and Safitri, Ida (2021) Predictors of pulmonary hypertension in children with left-to-right shunting in acyanotic congenital heart disease. Paediatrica Indonesiana (Paediatrica Indonesiana), 61 (3). 119 – 124. ISSN 00309311

[thumbnail of Weny_KKMK.pdf] Text
Weny_KKMK.pdf - Published Version
Restricted to Registered users only

Download (233kB) | Request a copy

Abstract

Background Left-to-right shunting in acyanotic congenital heart disease (CHD) is the most common type of defect in childhood heart disease. Limited access to specialist health services causes delays in CHD management. In limited resource settings, identification of factors that influence the occurrence of pulmonary hypertension is important in order to decide which patients should be prioritized for defect closure to prevent further complications. Objective To determine predictive factors of pulmonary hypertension after a left-to-right shunt CHD diagnosis. Methods This retrospective cohort study included children aged 1 month to 17 years with isolated atrial septal defect, or ventricular septal defect, or patent ductus arteriosus. Potential predictors studied were iron deficiency anemia, mitral regurgita-tion, pneumonia, and heart failure. Bivariate analysis was done with Chi-square test and multivariate analysis was done with Cox regression to determine the hazard ratio. Results Pulmonary hypertension occurred in 68 of 176 subjects. Iron deficiency anemia, mitral regurgitation, and pneumonia were not predictive factors of pulmonary hypertension. However, heart failure was a significant predictive factor for pulmonary hyperten-sion, with a hazard ratio of 4.1 (95CI 2.2 to 7.5; P=0.001). Conclusions Heart failure is a predictive factor of pulmonary hypertension in children with left-to-right shunting in acyanotic CHD. Paediatr Indones. 2021;61:119-24;. © 2021, Indonesian Pediatric Society Publishing House. All rights reserved.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: pulmonary hypertension; congenital heart disease; predictor factors; left-to-right shunting
Subjects: R Medicine > RB Biomedical Sciences
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 17 Sep 2024 07:20
Last Modified: 17 Sep 2024 07:20
URI: https://ir.lib.ugm.ac.id/id/eprint/4844

Actions (login required)

View Item
View Item