Hadibrata, Exsa and Farishal, Ahmad and Ali, Zulfikar and Danarto, R. (2021) Tamsulosin and Sodium Diclofenac as an Effective Therapy to Reduce Pain After Ureteral Stent Removal: A Prospective, Double Blinded Randomized Placebo Controlled Trial. Urology Journal, 18 (1). 111 – 116. ISSN 17351308
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Abstract
Purpose: This study was conducted to determine the effects of tamsulosin and diclofenac sodium use on patients’ pain perception after ureteral stents removal. Materials and Methods: This study was a randomized control trial with double-blinded design. Eighty patients who underwent ureteral stent removal surgery at Kardinah Hospital during January to March 2017 were divided into four groups. The following medications were administered for two days, (A) placebo tid, or (B) diclofenac sodium 50 mg bid, or (C) tamsulosin 0.2 mg sid, or (D) combination of tamsulosin and diclofenac sodium. Analgesic effects were assessed with the Visual Analog Scale (VAS). Relationships among variables were assessed using one-way ANOVA and post hoc tests. Results: The surgical procedure for ureteral stent removal consisted of 48 (60) male and 32 (40) female. The average age of group A, B, C, and D were 51.0, 51.9, 47.6, and 47.3 years, and the average stent dwell time was 6.3 weeks. VAS values of the entire experimental group were lower than the control group on the first day until the second day after the stent removal (p < 0.05). In the experimental group, there was no difference between group B and C (p > 0.05). Group D showed better analgesic effects than group B and C (p < 0.05). No severe side effects were observed. Conclusion: The result shows that combination therapy of diclofenac sodium and tamsulosin is better in reducing the pain after ureteral stent removal compared to the admission of a single placebo, tamsulosin, or diclofenac sodium therapy. © 2021. All Rights Reserved.
Item Type: | Article |
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Additional Information: | Cited by: 1 |
Uncontrolled Keywords: | Adult; Device Removal; Diclofenac; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Stents; Tamsulosin; Ureter; diclofenac; tamsulosin; adult; comparative study; controlled study; device removal; double blind procedure; drug combination; female; human; male; middle aged; postoperative pain; prospective study; randomized controlled trial; stent; surgery; ureter |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Biomedical Sciences |
Depositing User: | Sri JUNANDI |
Date Deposited: | 17 Sep 2024 07:25 |
Last Modified: | 17 Sep 2024 07:25 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4845 |