Wibowo, R. Agus and Hastuti, Pramudji and Susanti, Vinayanti (2021) Polymorphism of thyroid hormones receptor, angiotensin-converting enzyme, and high blood pressure in childbearing age women with hyperthyroidism. Open Access Macedonian Journal of Medical Sciences, 9 (A). 387 – 392. ISSN 18579655
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Abstract
AIM: This study aimed to investigate the association between two polymorphisms of thyroid hormone receptor and renin-angiotensin system (THRA C/T and angiotensin-converting enzyme (ACE) I/D) genes with hypertension in childbearing age women with hypertension. METHODS: This was a case–control study including 35 cases and 40 matched control subjects. The case group was hyperthyroid women with hypertension while the control group was hyperthyroid women with normotension. The polymorphisms were identified by a classical polymerase chain reaction. RESULTS: The THRA C/T gene and ACE I/D polymorphisms were not associated with the hypertension while the genotype frequencies in hyperthyroid women with hypertension were as follows: CC genotype was 25.71, CT genotype was 54.29, and TT genotype was 20.00. The ACE I/D genotype frequencies in hyperthyroid women with hypertension were as follows: II genotype was 23.53, whereas in hyperthyroid women without hypertension, the I/D genotype frequencies were CC: 7.50, CT: 72.50, and TT: 20.00. There were no differences in age, thyroid-stimulating hormone, FT4, systolic blood pressure (SBP), diastolic BP between subgroups in ACE I/D, and at THRA rs-939348. There was a significant difference in the levels of FT4 concentrations in THRA rs-939348. Hypertension groups have higher SBP than controls. Genotype II had higher SBP but it was not statistically significant, while individuals with allele I had SBP higher than D allele. CONCLUSIONS: The I allele of the ACE gene is involved in susceptibility to hypertension and polymorphism in THRA increasing concentration of FT4. There was no statistically significant difference in blood pressure between hyperthyroid women with or without hypertension. © 2021 R. Agus Wibowo, Pramudji Hastuti, Vinayanti Susanti.
Item Type: | Article |
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Additional Information: | Cited by: 0; All Open Access, Gold Open Access |
Uncontrolled Keywords: | dipeptidyl carboxypeptidase; thyroid hormone; thyroid hormone receptor; thyroxine; Article; blood pressure; case control study; controlled study; diastolic blood pressure; DNA extraction; DNA polymorphism; enzyme linked immunosorbent assay; female; gene frequency; genetic polymorphism; genetic susceptibility; genotype; human; hypertension; hyperthyroidism; major clinical study; observational study; polymerase chain reaction; pregnancy; renin angiotensin aldosterone system; restriction fragment length polymorphism; risk factor; single nucleotide polymorphism; systolic blood pressure |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition |
Depositing User: | Sri JUNANDI |
Date Deposited: | 18 Sep 2024 01:33 |
Last Modified: | 18 Sep 2024 01:33 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4848 |