The Potential of hsa-mir-106b-5p as Liquid Biomarker in Prostate Cancer Patients in Indonesia

Bonnu, Christin H and Ramadhani, Anggia N and Saputro, Ranu B and Sesotyosari, Salsabila L. and Danarto, R. and Astuti, Indwiani and Haryana, Sofia M (2021) The Potential of hsa-mir-106b-5p as Liquid Biomarker in Prostate Cancer Patients in Indonesia. Asian Pacific Journal of Cancer Prevention, 22 (3). 837 – 842. ISSN 15137368

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Abstract

Purpose: This study aims to explore the potential of hsa-mir-106b-5p as a new liquid biomarker for prostate cancer sufferers in Indonesia. Methods: Analysis of hsa-mir-106b-5p expression of two tissue samples from BPH patients and two PCa patients used NanoString nCounter Expression Assay then validated by qRT-PCR using 10 patient urine samples for prostate cancer and BPH. Furthermore, analysis of the role of hsa-mir-106b-5p in prostate cancer was carried out bioinformatically. Results: The results of this study indicated that the expression of hsa-mir-106b-5p in prostate cancer tissue was 1.23 times higher than that of BPH and urine of Indonesian patients (1.72 times). Moreover, this miRNA was upregulated in prostate cancer cells compared to normal cells 1.37 times. The hsa-mir-106b-5p appeared to be involved in the development of prostate cancer through the binding of genes involved in endoplasmic reticulum stress pathways and tumor suppressor genes. Conclusion: hsa-mir-106b-5p could modulate prostate cancer by interfering with the endoplasmic reticulum stress repair pathways and decreasing the expression of tumor suppressor genes involved in many biological processes. These updates our understanding of the role of hsa-mir-106b-5p in cancer and its potential as a candidate of a biomarker for clinical diagnosis of prostate cancer. © 2021. All Rights Reserved.

Item Type: Article
Additional Information: Cited by: 7; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Biomarkers, Tumor; Endoplasmic Reticulum Stress; Humans; Indonesia; Male; MicroRNAs; Prostatic Hyperplasia; Prostatic Neoplasms; microRNA; MIRN106 microRNA, human; tumor marker; endoplasmic reticulum stress; genetics; human; Indonesia; male; metabolism; prostate hypertrophy; prostate tumor; urine
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 17 Sep 2024 03:35
Last Modified: 17 Sep 2024 03:35
URI: https://ir.lib.ugm.ac.id/id/eprint/4873

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