Fahmi, Moh Nailul and Pradjatmo, Heru and Astuti, Indwiani and Nindrea, Ricvan Dana (2021) Cytokines as Prognostic Biomarkers of Epithelial Ovarian Cancer (EOC): A Systematic Review and Meta-Analysis. Asian Pacific Journal of Cancer Prevention, 22 (2). 315 – 323. ISSN 15137368
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Abstract
Objectives: The value of cytokines as epithelial ovarian cancer (EOC) prognostic factors has been widely investigated. This study aimed to determine the role of single cytokine as a biomarker prognosis in EOC. Materials and Methods: We conducted a systematic review and meta-analysis of studies reporting cytokine as the prognostic predictor in EOC based on PRISMA guideline. We included English articles investigating associations of preoperative cytokines level in tissue, blood or ascites with overall survival (OS) or disease-free survival (DFS) from PUBMED and EBSCO. Summary hazard ratios (HRs) and confidence intervals (CIs) were calculated. Results: Fifty studies investigating twenty types of cytokines in tumor tissue, serum, and ascites from 5,376 patients were included. Pre-operative high VEGF level was associated with poor OS (HR 2.28, 95CI 1.28, 3.28) and DFS (HR 2.13, 95%CI 1.63, 2.78) in serum and OS (HR 1.80, 95%CI 1.45, 2.23) in tissue. IL-6 level in blood was associated with DFS (HR 1.60, 95%CI 1.21, 2.11). There was no single cytokine which investigated by at least 2 studies reporting hazard ratio in ascites, so we did not conduct the meta-analysis. Other cytokines (serum IL-8; ascites fluid IL-8, IL-10, IFN-γ, TNF-α; and ovarian tissue TGF-α, CSF-1, IL-10,TGF-β1, IL-17) associated with the poorer prognosis, could not be pooled due to lack of studies. Conclusion: Pre-operative VEGF level in serum and tissue specimen seem to be the potential candidate of an unfavorable prognostic biomarker for EOC. The evidence was lacking to support the other cytokines investigated in blood, tissue and ascites as prognostic biomarkers for EOC. © This work is licensed under a Creative Commons AttributionNon Commercial 4.0 International License.
Item Type: | Article |
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Additional Information: | Cited by: 9; All Open Access, Gold Open Access, Green Open Access |
Uncontrolled Keywords: | Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cytokines; Female; Humans; Prognosis; cytokine; tumor marker; diagnosis; female; human; meta analysis; metabolism; mortality; prognosis |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition |
Depositing User: | Sri JUNANDI |
Date Deposited: | 17 Sep 2024 03:54 |
Last Modified: | 17 Sep 2024 03:54 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/4877 |