The Evaluation of Cytotoxic Properties from CCB-2 Sugar Complexes Against TNBC and Non-TNBC Cells

Jenie, Riris Istighfari and Utomo, Rohmad Yudi and Susidarti, Ratna Asmah and Novitasari, Dhania and Kirihata, Mitsunori and Meiyanto, Edy (2021) The Evaluation of Cytotoxic Properties from CCB-2 Sugar Complexes Against TNBC and Non-TNBC Cells. Asian Pacific Journal of Cancer Prevention, 22 (1). 151 – 155. ISSN 15137368

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Abstract

Objective: The progress from Boron Neutron Capture Therapy (BNCT) development urged us to explore new targeted and selective boron carriers. Firstly, we reported the successful synthesis of CCB-2 which exerts a cytotoxic effect against triple negative breast cancer (TNBC) cells. We introduced the new modification of CCB-2 with sugar and alcohol sugars to enhance its solubility in hoping to increase cellular uptake. Methods: CCB-2 fructose complex (CCB-2-F), CCB-2 sorbitol complex (CCB-2-Sor), and CCB-2 xylitol complex (CCB-2-Xy) were obtained with small size within nano-specific particle. All the compounds were then determined for their cytotoxic activities through MTT assay. Results: All compounds were performed cytotoxic activities against TNBC 4T1 and HER-2 positive MCF-7/ HER2 cells with good selectivity when tested in immortalized fibroblast cells. Conclusion: Overall, we provided a new modification of CCB-2 through complexation with sugars. Still, further evaluations are needed to develop more efficient CCB-2 as the new candidate of anticancer agent, notably in breast cancer. © 2021. All rights reserved.

Item Type: Article
Additional Information: Cited by: 3; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Antineoplastic Agents; Apoptosis; Boron Compounds; Breast Neoplasms; Cell Proliferation; Female; Humans; Sugars; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; antineoplastic agent; boron derivative; carbohydrate; apoptosis; breast tumor; cell proliferation; chemistry; female; human; pathology; triple negative breast cancer; tumor cell culture
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 12 Sep 2024 08:26
Last Modified: 12 Sep 2024 08:26
URI: https://ir.lib.ugm.ac.id/id/eprint/4928

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